细胞免疫和体液免疫功能检测对重症结核病患者的临床意义  

Clinical significance of cellular immunity and humoral immunity for patients with severe tuberculosis

作　　者：毛敏杰[1] 汪彩红 潘蕾[1] 

机构地区：[1]浙江省中西医结合医院结核ICU,杭州310003

出　　处：《中华危重症医学杂志（电子版）》2015年第2期34-36,共3页Chinese Journal of Critical Care Medicine:Electronic Edition

基　　金：浙江省中医药科技计划项目(2011ZA084);浙江省医药卫生科技计划项目(2014KYA182)

摘　　要：目的探讨重症结核病患者细胞免疫和体液免疫的变化情况。方法将2 713例结核病患者根据病情分成普通结核组(2 557例)及重症结核组(156例),比较并分析两组患者外周血CD3+T细胞、CD4+T细胞、CD8+T细胞、自然杀伤(NK)细胞、B细胞、免疫球蛋白(Ig)A、Ig G、Ig M、补体C3及补体C4的水平。结果重症结核组患者外周血CD3+T细胞、CD4+T细胞、NK细胞及B细胞较普通结核组患者均明显下降(P均<0.05),而CD8+T细胞两组比较,差异无统计学意义(P>0.05)。同时,重症结核组患者外周血Ig A、Ig G、Ig M、补体C3及补体C4均较普通结核组患者均显著下降(P均<0.05)。结论重症结核病患者的细胞免疫和体液免疫均比普通结核病患者受到了更大程度的损害。Objective To explore the changes and clinical significance of cellular immunity and humoral immunity in patients with severe tuberculosis （TB）. Methods A total of 2 713 TB patients were divided into the ordinary TB group （2 557 cases） and severe rib group （156 cases）. Peripheral blood lymphocyte CD3^＋T cell, CD4^＋T cell, CD8^＋T cell, natural killer cell, B cell, the peripheral plasma level of immunoglobulin （Ig）A, IgG, IgM, complement C3 and C4 were analyzed and compared. Results Compared with the ordinary TB group, the ratio of CD3^＋T cell, CD4＋T cell natural killer cell and B cell in the severe TB group were all decreased （all P 〈 0.05）, but the ratio of CD8^＋T cell showed no significant difference between the two group （P 〉 0.05）. Meanwhile, the plasma level of IgA, IgG, IgM and complement C3 and C4 in the severe TB group were all lower than those in the ordinary TB group （all P〈0.05）. Conclusion The cellular immunity and hunmral immunity in the severe TB patients suffered more damage as compare with the ordinary TB patients.

关 键 词：重症结核 免疫 细胞 免疫 体液 

分 类 号：R52[医药卫生—内科学]