急性脑梗死干预治疗后血清同型半胱氨酸水平变化的研究  

Study on the Change of Serum Homocysteine Level After the Intervention Treatment of Acute Cerebral Infarction

作　　者：谭兴文[1] 胡轶虹[1] 戴绘[1] 纪影实[2] 庆疆[1] 刘松 张征骄[1] 

机构地区：[1]吉林省人民医院,长春130021 [2]吉林大学医学部药理教研室,长春130000

出　　处：《中国卫生标准管理》2015年第13期184-186,共3页China Health Standard Management

基　　金：吉林省科技厅自然科学基金项目(201015219)

摘　　要：目的研究血清同型半胱氨酸(Hcy)水平与急性脑梗死发病的关系及药物干预治疗后同型半胱氨酸水平变化及预后分析。方法收集100例急性脑梗死患者,治疗组50例、对照组50例,分别于治疗前及治疗后7天采取血液标本,采用酶联免疫法测定Hcy,比较治疗组与对照组血清Hcy水平变化,治疗前及治疗后14天进行神经功能评估,治疗后3个月进行日常生活能力评估,比较近期疗效及远期预后。结果治疗组和对照组血清Hcy水平在治疗前均有不同程度升高,治疗后Hcy水平下降,两组比较差异有统计学意义(P<0.05)。治疗组和对照组治疗后NIHSS评分降低,两组比较差异有统计学意义(P<0.05)。结论高Hcy血症与急性脑梗死的发生密切相关,急性期应用尤瑞克林能降低Hcy水平,早期改善症状,为防治脑梗死进展提供新的理论依据。Objective To study the relationship of serum homocysteine（Hcy）and the aetiological agent of acute cerebral infarction. And the change of Hcy level after drug intervention. Methods 100 cases of patients with acute cerebral infarction were divided into control group and treatment group,50 cases of each group. 7 days before and after treatment the blood samples of the patients were taken. The content of Hcy was detected by enzyme linked immunosorbent assay. The contents of Hcy were compared between two groups. 14 days before and after treatment,the nerve functional assessment was evaluated. 3 months after treatment,the ability of daily life was evaluated. The curative effect and prognosis were compared. Results The levels of Hcy in the treatment group and the control group were increased before the treatment. After treatment,the level of Hcy was reduced,there was significant difference between two groups（P＆lt;0.05）. After treatment,the NIHSS score was lower than before in the treatment group and control group,there was significant difference between two groups（P＆lt;0.05）. Conclusion There is a very close relationship between high Hcy hyperlipidemia and acute cerebral infarction. Urinarykal id can reduce the level of Hcy at acute stage. The medicine can also improve the early symptoms. The medicine can provide a new theoretical basis for the prevention and treatment of cerebral infarction.

关 键 词：同型半胱氨酸 急性脑梗死 尤瑞克林 

分 类 号：R446[医药卫生—诊断学]