骨桥蛋白在结直肠癌及其肝转移组织的表达及临床意义  

Expression of osteopontin in colorectal cancer and hepatic metastatic cancer tissues and its clinical significance

作　　者：吕远[1] 李世拥[2] 安萍[2] 蔡慧云[2] 

机构地区：[1]第三军医大学,重庆400038 [2]解放军北京军区总医院普通外科

出　　处：《中华普通外科杂志》2015年第5期383-385,共3页Chinese Journal of General Surgery

基　　金：国家自然科学基金资助项目（30772118,81041025）

摘　　要：目的 探讨骨桥蛋白在结直肠癌及其肝转移组织中的表达及与临床病理的关系.方法 收集2008年1月至2009年12月行手术治疗且随访完整的结直肠癌患者的组织标本76例,包括取同一患者癌旁＞ 10 cm正常黏膜组织30例,肝转移组织16例,采用免疫组织化学方法检测骨桥蛋白表达.结果 骨桥蛋白在正常黏膜、结直肠癌组织和肝转移癌组织中的表达率分别为：6.7％（2/30）、69.7％ （53/76）和75.0％ （12/16）.骨桥蛋白在结直肠癌组织和肝转移组织中的表达明显高于正常黏膜,差异均有统计学意义（分别x2=34.273,23.014,均P＜0.001）;骨桥蛋白的高表达与结直肠癌的浸润深度、分化程度、淋巴结和肝转移有关（分别x2=14.347,6.577,7.278,5.537,均P＜0.05）,与患者的性别和年龄无关.骨桥蛋白（＋）患者中位生存期及5年生存率均显著低于骨桥蛋白（-）患者.结论 骨桥蛋白的表达与结直肠癌的侵袭和转移密切相关,可能成为判断结直肠癌预后的重要指标.Objective To investigate the expression of osteopontin in colorectal cancer and hepatic metastatic cancer and its clinical significance.Methods The expression of osteopontin in 76 cases of colorectal cancer tissues,30 para carcinoma normal mucosa,liver metastatic tumor tissues in 16 patients was examined by immunohistochemical SP staining method.Results The expression rates of osteopontin in normal mucosa,colorectal cancer tissues and liver metastatic cancer tissues were 6.7% （2/30）,69.7% （53/76）,75.0% （12/16） respectively.The expression rates of osteopontinin colorectal cancer and liver metastatic cancer was significantly higher than those in the normal mucosa （respectively x2 =34.273,23.014,all P 〈 0.001）.The expression of osteopontin was related to infiltration depth,lymph node metastasis,and distant metastasis （respectively x2 =14.347,6.577,7.278,5.537,all P 〈 0.05）.There was no significant difference in the sex and age.Kaplan-Meier survival analysis showed that patients with osteopontin positive had poor prognosis compared with osteopontin negative patients （P 〈 0.001）.Conclusions The expression of osteopontin is closely related to the invasion and metastasis of colorectal carcinoma,a hopeful indicator for the prognosis of colorectal cancer.

关 键 词：结直肠肿瘤 预后 骨桥蛋白 

分 类 号：R543.5[医药卫生—心血管疾病]