Smadl与糖尿病肾病的研究进展  

Research progress in Smadl and diabetic nephropathy

作　　者：周颖[1] 陈纤纤[1] 冯烈[1] 

机构地区：[1]暨南大学第一临床医学院内分泌及代谢科,广州510630

出　　处：《中华内分泌代谢杂志》2015年第5期468-470,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：糖尿病肾病（diabetic nephropapthy，DN）是导致终末期肾病的常见原因，早期诊断、及时治疗有助于延缓其进展。Smad蛋白是介导转化生长因子p超家族胞内信号转导途径的一组蛋白质。新近研究发现Smadl蛋白在DN肾纤维化过程中扮演重要角色。尿Smadl出现在DN早期阶段，有望成为早期诊断DN的非侵入性指标。Diabetic nephropapthy （DN） is a common cause of end-stage renal disease. Early diagnosis and treatment are significant for delaying the development of DN. Smad proteins mediate transforming growth factor ~, superfamily intracellular signal transduction. Recent studies have found that Smadl protein plays an important role in the process of renal fibrosis. Urine Smadl emerges in the early stage of DN, which is expected to be a non-invasive indicator in early diagnosis of DN.

关 键 词：糖尿病肾病 Smad1蛋白 系膜基质扩张 

分 类 号：R587.2[医药卫生—内分泌]