磁共振扩散峰度成像在星形细胞肿瘤分级中的应用  被引量:4

Application of MR diffusion kurtosis imaging in grading of astrocytic tumors

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作  者:杨明瑞[1] 姜兴岳[1] 聂泰明[1] 王静[1] 张迪[1] 任文[1] 

机构地区:[1]滨州医学院附属医院影像科,山东滨州256603

出  处:《实用放射学杂志》2015年第5期714-717,共4页Journal of Practical Radiology

基  金:山东省自然科学基金资助项目(ZR2011HL038).

摘  要:目的:研究磁共振扩散峰度成像(DKI)在颅内星形细胞肿瘤分级中的应用价值。方法收集经手术病理证实的星形细胞肿瘤患者31例,其中低级别(WHO 分级Ⅰ级或Ⅱ级)14例,高级别(WHO 分级Ⅲ级或Ⅳ级)17例。应用德国 Siemens 公司3.0T超导型 MR 扫描仪对患者进行术前常规 MRI 及 DKI 扫描,分别测量肿瘤实质区及对侧正常脑白质区的平均峰度(MK)、径向峰度(RK)及轴向峰度(AK)值。将肿瘤实质部分的 MK、RK 及 AK 值与正常对侧白质的 MK、RK 及 AK 值比较;比较高、低级别星形细胞肿瘤之间 MK、RK 及 AK 值的差异。结果星形细胞肿瘤 MK、RK 及 AK 值均低于对侧正常脑白质的 MK、RK 及 AK 值。MK、RK 及 AK 值均随肿瘤级别增高而增高,且上述差别在高、低级别肿瘤之间均具有统计学意义(P〈0.05)。结论 DKI 获得的MK、RK 及 AK 值一定程度上反映了星形细胞肿瘤实质区组织结构的变化,有助于对高、低级别肿瘤进行术前判定,从而更好地优化治疗方案。Objective To investigate the value of magnetic resonance (MR)diffusion kurtosis imaging (DKI)in diagnostic classi-fication of astrocytic tumors.Methods 31 patients with astrocytic tumors confirmed by operation and pathology were collected,in-cluding low-grade tumors (WHO gradeⅠ and Ⅱ)in 14 and high-grade ones (WHO grade Ⅲ and Ⅳ)in 1 7.Routine MRI and DKI scan were preoperatively conducted using Siemens 3.0T MR scanner.Mean kurtosis (MK),radial kurtosis (RK)and axial kurtosis (AK)values were calculated in the solid portion of the tumors and the contralateral normal white matter.Results The MK,RK and AK values in tumors were lower than those in contralateral normal white matter,and were significantly higher in high-grade tumors than those in low-grade ones (P〈0.05).Conclusion The MK,RK and AK values obtained by DKI reflect the histological structure changes of the astrocytic tumors.DKI is helpful for the diagnostic classification of astrocytic tumors,exhibiting more value in optimi-zing the treatment.

关 键 词:扩散峰度成像 星形细胞肿瘤 分级 

分 类 号:R445.2[医药卫生—影像医学与核医学] R739.41[医药卫生—诊断学]

 

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