胚胎发育中血管新生的研究  

The Progress of Embryonic Angiogenesis

作　　者：高成[1] 闫小毅[1] 卓巍 朱飚[2] 周天华[1] 

机构地区：[1]浙江大学基础医学院细胞生物学系,杭州310058 [2]浙江省人民医院,杭州310058

出　　处：《中国细胞生物学学报》2015年第5期720-727,共8页Chinese Journal of Cell Biology

基　　金：国家科技部重大科学研究计划(批准号:2012CB945004);国家自然科学基金重大项目(批准号:31190063);浙江省实验动物科技计划(批准号:2012C37089)资助的课题~~

摘　　要：在胚胎发育中,心血管系统最早发育并发挥运输氧和营养物质的功能。在原肠运动时期,中胚层细胞在相邻内胚层细胞信号的诱导下分化产生内皮细胞,从而开始形成血管系统。血管新生是形成完整血管系统的重要过程,主要包括出芽式血管新生和套叠式血管新生两种方式。出芽式血管新生最为普遍,主要包括基底膜的降解、内皮细胞的迁移和增殖、管腔形成和血管的成熟与稳定四步。由于血管新生对胚胎发育以及许多生理过程均发挥重要作用,血管新生受到多条信号通路的精密调控。该文从内皮细胞的来源、血管新生的过程及信号调控三个方面就近年来胚胎发育中血管新生的研究作简要综述。Cardiovascular system is essential for the transport of oxygen and nutrients to tissues. Therefore, cardiovascular system is the first organ to develop and reach a functional state during embryogenesis. Blood vessel formation initiates during gastrulation, wherein mesoderm ceils differentiate into endothelial cells by the induc- ing signals from the endoderm. Angiogenesis is a critical event for the formation of the vascular network, which contains two models： sprouting angiogenesis and intussusceptive angiogenesis. Sprouting seems to be the most extensive mechanism, which undergoes the following progression： the destruction of the basement membrane, the migration and proliferation of endothelial cells, lumen formation, vessel maturation and stabilization. This paper re- views the progress of embryonic angiogenesis in recent years from three aspects： the origin of endothelial cells, the process of angiogenesis and the regulation of angiogenesis.

关 键 词：胚胎发育 内皮细胞 血管新生 信号转导 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]