血清葡萄糖参考物质在24种常规分析系统上的互通性研究  

The commutability of reference materials for serum glucose measurements

作　　者：张天娇[1] 曾洁[1] 王默[1] 张传宝[1] 张江涛[1] 赵海建[1] 汪静[1] 王冬环[1] 周伟燕[1] 马嵘[1] 胡翠华[1] 陈文祥[1] 

机构地区：[1]北京医院卫生部临床检验中心生化室,100730

出　　处：《中华检验医学杂志》2015年第5期296-300,共5页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金（81301488）;国家科技基础性工作专项（2013FYl13800）

摘　　要：目的：评价有证参考物质、室间质量评价计划材料、校准品等血清葡萄糖参考物质在24种常规分析系统上的互通性。方法方法学评价。用血清葡萄糖同位素稀释液相色谱串联质谱法为比对方法，血糖常规方法的24种测定系统为待评方法，测定35份单人份冰冻血清和多种参考物质，评价这些物质在各个系统上的互通性。结果5种有证参考物质、2种正确度验证计划材料、5种校准品在参加评价的24种系统上具有良好的互通性。其他参考物质显示不同程度的互通性问题。结论应充分重视互通性问题对血清葡萄糖测定量值传递的影响。（中华检验医学杂志，2015，38：296－300）Objective To evaluate the commutability of certified reference materials, external quality assessment program materials and calibrators for serum glucose measurements which were performed in 24 routine measurement procedures.Methods 35 fresh patient specimens and some reference materials were analyzed by isotope dilution liquid chromatography tandem mass spectrometry （ as the comparative method） and 24 routine measurement procedures （as the evaluated methods）.The relationships between the results from the evaluated method and the comparative methods were evaluated to identify the commutability.Results It showed that 5 certified reference materials, 2 trueness verification materials, and 5 calibrators were commutable in all 24 routine measurement procedures.The other samples were displayed the presence of commutability issue in different degrees.Conclusion It is important to pay more attention to the problems brought by commutability of reference materials in clinical laboratory.

关 键 词：血糖 参考标准 参考值 

分 类 号：R446.1[医药卫生—诊断学]