播散性黄瘤并发垂体、骨受累及尿崩症  

Xanthoma disseminatum with pituitary involvement, osteoclasia and diabetes insipidus: a case report

作　　者：徐晨琛[1] 刘跃华[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院皮肤科,北京100730

出　　处：《临床皮肤科杂志》2015年第6期380-382,共3页Journal of Clinical Dermatology

摘　　要：报告1例播散性黄瘤并发垂体、骨受累及尿崩症。患者女,14岁。全身丘疹伴多饮及多尿1年余。家族中无类似疾病患者。皮肤科检查:双眼睑及睑缘、口周、双侧腋下、腹部及背部多发粟粒至黄豆大棕红色丘疹,表面光滑、质韧,无压痛。口咽部及肛周黏膜未见异常。实验室及辅助检查:血脂无异常;胸部CT示T4椎体内可见骨破坏。皮损组织病理检查:表皮棘层不规则增厚,真皮浅层淋巴细胞及组织细胞浸润,可见泡沫细胞及多核巨细胞。免疫组化:CD68(+++),S-100蛋白(-),CD1a(-)。诊断:播散性黄瘤;中枢性尿崩症。A case of xanthoma disseminatum with pituitary involvement, osteoelasia and diabetes insipidus is reported. A 14- year-ohd girl presented with papules on the whole body with polyuria and polydipsia for more than a year. Family history of the similar manifestations was negative. Dermatological examination revealed muhiple, firm, painless, reddish-brown papt, les, sized from miliary to soybean on the eyelid and palpebral margin, mouth, bilateral axillae, abdomen and back. Oral and anal mucosae were normal. Laboratory and auxiliary examination showed blood lipid was normal, and chest CT scan showed osteocla- sia in the fourth thoracic vertebra. Histopathological examination revealed irregular acanthosis, lymphocytes and histiocytes infil- Irated in the superficial layer of the dennis. Foam cells and muhinucleated giant cells also could be found in the dermis. Im- munohistochemical staining was negative for S-100 protein and CDla, but strong positive for CD68. The diagnosis of xanthoma disseminatum and diabetes insipidus were made.

关 键 词：播散性黄瘤 骨损害 尿崩症 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]