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机构地区:[1]南昌大学第一附属医院-整形美容科,江西省南昌市330006
出 处:《中国组织工程研究》2015年第15期2420-2424,共5页Chinese Journal of Tissue Engineering Research
摘 要:背景:瘢痕疙瘩是整形外科中非常棘手的问题,其发病机制十分复杂,是多种因素共同作用的结果,如多种细胞因子,信号转导通路,细胞外基质等。目前关于机械力及其力学信号转导通路影响瘢痕疙瘩的进展研究已开始受到广泛关注,并逐渐成为研究瘢痕疙瘩发病机制的热点之一。目的:总结参与瘢痕疙瘩发病机制的相关机械信号转导通路进展,为进一步认识瘢痕疙瘩发病机制及防治瘢痕疙瘩的相关研究提供新思路。方法:应用计算机检索Pub Med数据库、Elsevier数据库2000年1月至2014年7月期间相关文章,检索词为"keloid,molecular mechanism,mechanical stress;cutaneous scar,mechanobiology,mechanosignaling pathway",限定文章语言种类为English。选择内容与瘢痕疙瘩相关分子信号转导机制及其参与其机械力改变的力学信号转导通路相关的文章,共纳入23篇文献。结果与结论:瘢痕疙瘩相关机械信号转导通路如转化生长因子β/Smad,MAPK,整合素,Wnt/β-catenin,Rho A/ROCK和肿瘤坏死因子α/核因子κB信号通路等在瘢痕疙瘩的形成及发展起着重要作用,多项临床实验也表明了部分机械信号转导通路抑制剂在伤口愈合或减轻瘢痕增生方面的有效性。从机械信号转导通路研究瘢痕疙瘩发病机制虽已取得一定的进展,但大部分还停留在动物实验阶段。其次,各个机械信号转导通路的相关性及交叉性还需深入研究,以便实现防治瘢痕疙瘩的突破。BACKGROUND: Keloid is a very challenging problem in plastic surgery. Its pathogenesis is very complex, resulting from the combined action of many factors, such as various cytokines, signal transduction pathways, extracellular matrix, etc. At present, a critical role for mechanical force and mechanotransduction in the pathogenesis of keloids has been broadly concerned and becomes the focus of studying the pathogenesis of keloids. OBJECTIVE: To summarize the progress of the mechanosignaling pathway involved in the pathogenesis of keloids in order to further understand the pathogenesis of keloids and provide new ideas for the prevention of keloids. METHODS: The Pub Med database and Elsevier database were retrieved for articles published from January 2000 to July 2014 by computer with key words of "keloid, molecular mechanism, mechanical stress, cutaneous scar, mechanobiology, mechanosignaling pathway" in English. A total of 23 articles were included which related to the molecular signal transduction mechanism and mechanosignaling pathway about keloids. RESULTS AND CONCLUSION: The mechanosignaling transduction pathways, such as transforming growth factor-β/Smad, MAPK, integrin, Wnt/β-catenin, Rho A/ROCK and tumor necrosis factor-α/nuclear factor-κB signaling pathway, play an important role in the formation and development of keloids. A number of clinical trials have also shown the effectiveness of a part of mechanosignaling transduction pathway inhibitors in wound healing and reducing scar hyperplasia. The research about mechanosignaling transduction pathways involved in keloidshas made some progress, but most still remain in animal experimental stage. Secondly, various mechanosignaling transduction pathways about correlation and intersectionality still need further studies to achieve a breakthrough in the prevention of keloids.
关 键 词:瘢痕疙瘩 信号传导 肿瘤坏死因子Α NF-κB 转化生长因子Β 组织构建 组织工程 机械信号转导通路
分 类 号:R318[医药卫生—生物医学工程]
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