急性冠脉综合征患者血浆chemerin和C反应蛋白水平升高  

The elevated levels of plasma chemerin and C-reactive protein in patients with acute coronary syndrome

作　　者：梁志山[1,2] 俞坤武 吴帮卫 钟禹成[1] 曾秋棠[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院心内科,湖北武汉430022 [2]广西壮族自治区柳州市工人医院心内科,广西柳州545005

出　　处：《细胞与分子免疫学杂志》2015年第7期953-956,共4页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金(81070237)

摘　　要：目的探讨急性冠脉综合征患者血浆趋化素(chemerin)和C反应蛋白(CRP)水平变化。方法用ELISA测定急性心肌梗死(AMI)组、不稳定型心绞痛(UA)组、稳定型心绞痛(SA)组及对照组血浆chemerin水平,免疫发光夹心法测定CRP水平。结果 AMI组和UA组血浆chemerin水平显著高于对照组和SA组,且AMI组血浆chemerin水平显著高于UA组。AMI组和UA组血浆CRP水平显著高于对照组和SA组。血浆chemerin水平与CRP、空腹血糖、左室舒张末期内径显著正相关,与左室射血分数显著负相关。结论急性冠脉综合征患者血浆chemerin和CRP水平升高。Objective To investigate the plasma levels of chemerin and C-reactive protein （CRP） in the patients with acute coronary syndrome. Methods The plasma levels of chemerin and CRP were respectively measured by ELISA and immune luminescence sandwich assay in 40 patients with acute myocardial infarction （AMI）, 40 patients with unstable angina （ UA）, 40 patients with stable angina （SA） and 40 control patients. Results The levels of chemerin and CRP were significantly higher in the AMI and UA groups than in the SA and control groups, and the level of chemerin was significantly higher in the AMI group than in the UA group. The level of chemerin was positively correlated with the level of CRP, fasting glucose and left ventricular end-diastolic diameter, but negatively correlated with left ventdcular ejection fraction. Conclusion The plasma levels of chemedn and CRP are elevated in patients with acute coronary syndrome.

关 键 词：急性冠脉综合征 CHEMERIN C反应蛋白 炎症 

分 类 号：R541.4[医药卫生—心血管疾病] R392.12[医药卫生—内科学]