肝癌患者微波消融后乙肝病毒再激活的前瞻性研究  

Hepatitis B virus reactivation in hepatocelinlar carcinoma patients after microwave ablation

作　　者：陆文[1] 范晴敏 吴盼盼[1] 徐中琪 许赟[1] 钱国军[1] 

机构地区：[1]第二军医大学东方肝胆外科医院微创1科,上海200438

出　　处：《中华肝胆外科杂志》2015年第5期297-300,共4页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的 探讨乙型肝炎相关性肝癌患者行微波消融（MWA）术后乙型肝炎病毒（HBV）再激活的风险及预后.方法 前瞻性研究72例符合入组标准的患者.其中30例为对照组,42例为预防性抗病毒组.探讨两组患者术后HBV再激活率及肝功能恢复情况等指标.结果 在随访期间8.3％ （6/72）患者出现乙肝病毒再激活.高HBV DNA载量和未行预防性抗病毒治疗是HBV再激活的独立危险因素.HBV再激活是肝癌复发的危险因素（P＜0.05）.结论 HBV再激活能导致肝癌复发,预防性抗病毒治疗能有效控制HBV再激活.Objective To investigate the risk factors of hepatitis B virus （HBV） reactivation after microwave ablation （MWA） and its prevention.Methods 72 patients who met the inclusion criteria were enrolled into the study.30 patients were in the control group and 42 patients in the prophylactic antivirus group.Results 8.3% （6/72） patients developed HBV reactivation.A high HBV DNA load and no prophylactic antivirus therapy were independent risk factors of viral reactivation.Conclusion Prophylactic antivirus therapy can prevent HBV reactivation.

关 键 词：肝癌 微波消融 乙肝病毒再激活 

分 类 号：R563.1[医药卫生—呼吸系统]