POR*28基因多态性与阿托伐他汀调脂疗效的关系  

Association between POR*28 polymorphism and lipid-lowering response to atorvastatin

作　　者：韦侃侃[1] 张莉蓉[2] 

机构地区：[1]郑州大学第四附属医院药学部,河南郑州450044 [2]郑州大学基础医学院药理学教研室,河南郑州450052

出　　处：《中国新药与临床杂志》2015年第5期372-375,共4页Chinese Journal of New Drugs and Clinical Remedies

基　　金：河南省杰出青年基金资助项目(074100510020)

摘　　要：目的观察POR*28基因多态性与阿托伐他汀调脂疗效的关系。方法采用聚合酶链反应-直接测序法对以阿托伐他汀治疗(20 mg,qn)30 d的185名高脂血症患者进行基因分型,比较治疗前后各基因型间血三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)水平的差别。结果 POR*28的基因变异率为41.6%,治疗前各基因型间TG、TC、LDL-C和HDL-C的浓度均无显著差异;治疗30 d后,纯合子等位基因TT型携带组LDL-C浓度显著低于CC型携带组[(2.46±0.37)mmol·L-1vs.(2.69±0.49)mmol·L-1,P=0.019],各基因组TG、TC浓度均无显著差异(P>0.05);TT型携带组HDL-C浓度有升高的趋势(P>0.05)。结论 POR*28基因多态性与阿托伐他汀降低LDL-C浓度有关。AIM To investigate the associations between POR＊28 polymorphisms and lipid-lowering response to atorvastatin. METHODS Genotypes were determined using polymerase chain reaction（PCR）-direct sequencing in 185 hyperlipidemic patients treated with atorvastatin 20 mg once daily for 30 days. Serum triglyceride（ TG）, total cholesterol（ TC）, low-density lipoprotein cholesterol（ LDL-C）, and high density lipoprotein cholesterol（HDL-C） levels were determined before and after the treatment. RESULTS Variant allele frequencies of POR＊28 was 41.6%. There were no statistically significant differences in the levels of TG, TC,LDL-C and HDL-C before treatment among the POR＊28 genotypes. After 30 days treatment, the level of LDLC after treated with atorvastatin was significantly decreased in subjects with homozygous for the T allele than forthe C allele of POR＊28（（ 2.46 ± 0.37） mmol·L-1vs.（ 2.69 ± 0.49） mmol·L-1, P = 0.019）. There were no significant differences in levels of TG and TC between the T and C alleles（ P 〉 0.05）. And the increased tendency was seen in the level of HDL-C（P 〉 0.05） in the T alleles. CONCLUSION POR＊28 polymorphism is related to LDL-C lowering response of atorvastatin.

关 键 词：多态性 单核苷酸 阿托伐他汀 血脂异常 

分 类 号：R972.6[医药卫生—药品]