文拉法辛联合安非他酮与单用文拉法辛治疗非典型抑郁的对照研究  

Comparison study of venlafaxine combined with bupropion versus single venlafaxine in treatment of atypical depression

作　　者：韩继阳[1] 战玉华[1] 夏静[1] 何强[1] 刘果[1] 王旭梅[1] 

机构地区：[1]中国医科大学附属盛京医院心理门诊,辽宁沈阳110817

出　　处：《中国新药与临床杂志》2015年第5期382-385,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的研究文拉法辛联合安非他酮治疗非典型抑郁的疗效及安全性。方法 95例非典型抑郁患者随机分为两组,研究组(n=49)给予文拉法辛(171±53)mg·d-1合并安非他酮(261±67)mg·d-1治疗,对照组(n=46)单用文拉法辛(174±52)mg·d-1治疗,疗程均为6周。采用汉密尔顿抑郁量表(HAMD-24)和大体评定量表(GAS)评定疗效,以治疗前后HAMD-24减分率≥50%作为判定显效率的依据;观察并比较两组的不良反应。结果本研究共完成83例,研究组42例,对照组41例。两组HAMD-24评分均较治疗前显著减少(P<0.01)。治疗第6周末,研究组HAMD-24评分显著低于对照组(10.83±8.84 vs.15.02±9.32,P<0.05),GAS评分显著高于对照组(69.43±10.39 vs.64.29±9.48,P<0.05)。研究组治疗显效率为79%,对照组51%,组间有非常显著差异(P<0.01)。两组不良反应均较轻微,总体发生率无显著差异(P>0.05)。结论文拉法辛联合安非他酮治疗非典型抑郁的疗效优于单用文拉法辛,且安全性相当。AIM To investigate the curative effect and safety of venlafaxine combined with bupropion in treatment of atypical depression. METHODS Ninety-five patients with atypical depression were randomly assigned into two group： 49 in test group and 46 in control group. The test group were treated with venlafaxine（ 171 ± 53） mg·d-1combined with bupropion（ 261 ± 67） mg·d-1and the control group were treated with venlafaxine（ 174 ± 52） mg·d-1for 6 weeks treatment. Hamilton Depression Scale（ HAMD-24） and Global Assessment Scale（GAS） were used to evaluate the curative effect, with the reducing score rate of HAMD-24≥ 50% for significant advancement, and adverse drug reactions of the two groups were observed and compared.RESULTS The study group completed 42 patients with 7 patients dropped, and the control group completed 41 patients with 5 patients dropped. After the treatment, HAMD scores in both groups were lower than scores of their baseline. At the end of 6 weeks treatment, HAMD-24 scores of the test group were significantly lower than those of the control group（10.83 ± 8.84 vs. 15.02 ± 9.32, P 〈 0.05）, and GAS scores of the test group were significantly higher than those of the control group（69.43 ± 10.39 vs. 64.29 ± 9.48, P 〈 0.05）. The apparent rate of the test group and control group were 79% and 51% respectively, with a significant difference（ P 〈0.01）. Adverse reactions of the two groups were both milder, and there were no significant differences in the overall incidence（ P 〉 0.05）. CONCLUSION The efficacy of venlafaxine combined with bupropion is better than that of single venlafaxine in the treatment of atypical depression, and the safety is equivalent.

关 键 词：文拉法辛 安非他酮 非典型抑郁 临床对照试验 治疗结果 

分 类 号：R971.4[医药卫生—药品]