盐酸二甲双胍在不同电极上的电化学行为及其分析应用  

Electrochemical behaviors of metformin hydrochloride at different electrodes and the application in bioanalysis

作　　者：赵灵芝[1,3] 赵柳 苗延青[1] 刘春叶[1] 

机构地区：[1]西安医学院药学院,西安710021 [2]北京农业质量标准与检测技术研究中心,北京100097 [3]陕西省生命分析重点实验室,陕西师范大学化学化工学院,西安710062

出　　处：《分析试验室》2015年第6期654-658,共5页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金(21305109,81202492,81302706);陕西省科学技术厅自然科学基础研究计划项目(2014JQ2073,2014K02-11-01);西安医学院博士启动基金(2012 Doc 09)资助

摘　　要：比较了盐酸二甲双胍（Met）在金电极、铂电极、玻碳电极上的电化学行为,结果表明Met在玻碳电极上具有最佳电化学信号;在此基础上,将单壁碳纳米管修饰的玻碳电极作为工作电极,在最佳实验条件下对Met进行检测,其响应电流与Met浓度在200~5000μmol/L范围呈良好的线性关系,定量限是100μmol/L,可用于检测尿液中的Met。This study compared the electrochemical behaviors of mefformin glassy carbon electrode, showing that the best electrochemical signals for hydrochloride at gold electrode and Met were attained at glassy carbon electrode. To further improve the detection sensitivity, single-walled carbon nanotubes were adopted to modifly glassy carbon electrode as the working electrode for Met detection. Under optimum conditions, the linear range was 200 - 5000 μmol/L with the limit of quantification of 100 μmol/L and high recovery was gained for the determination of Met in spiked urine samples. This proposed method laid the foundation for fast and simple electrochemical determination of dopamine.

关 键 词：盐酸二甲双胍 单壁碳纳米管 电化学行为 

分 类 号：TQ460.7[化学工程—制药化工]