川黄柏醇提物的抗炎作用及机制的研究  

Study on the anti-inflammatory effects and its mechanism of the alcohol extracts of Phellodendri chinensis cortex

作　　者：欧丽兰[1] 余昕[1] 张椿[1] 朱烨[1] 

机构地区：[1]泸州医学院药学院,四川泸州646000

出　　处：《华西药学杂志》2015年第3期308-309,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的观察川黄柏醇提物(AEPC)的抗炎作用并探讨其机制。方法采用乙酸致小鼠腹腔毛细血管通透性增加和角叉菜胶诱导大鼠胸膜炎模型来观察AEPC的抗炎作用;测定胸膜炎大鼠胸腔渗出液中前列腺素E2(PGE2)、肿瘤坏死因子-α(TNF-α)和白细胞介素-1β(IL-1β)的含量及肺组织中TNF-α、IL-1β、丙二醛(MDA)的含量,探讨其抗炎机制。结果与模型组比较,AEPC中、高剂量可显著抑制小鼠腹腔毛细血管通透性增加;还可抑制胸膜炎大鼠胸腔液中PGE2、TNF-α、IL-1β含量的升高;AEPC高剂量能抑制胸膜炎大鼠肺组织中TNF-α、IL-1β、MDA含量的升高,中剂量能抑制肺组织中IL-1β含量的升高。结论 AEPC具抗炎作用,其抗炎机制可能与影响炎症介质的产生和抗氧化作用有关。OU Li-lan;YU Xin;ZHANG Chun;ZHU Ye;Department of Pharmacy,Luzhou Medical College; OBJECTIVE To observe the anti-inflammatory effects of alcohol extracts of Phellodendri chinensis cortex（ AEPC） and explore its mechanism. METHODS The anti-inflammatory effect of AEPC was observed by the acetic acid-induced mice permeability accentuation. Model and the carrageenan-induced rat acute pleurisy model. The anti-inflammatory mechanisms were investigated by detecting the contents of prostaglandins（ PGE2）,tumor necrosis factor-alpha（ TNF-α）,interleukin-1β（ IL-1β） in exudates,and the TNF-α,IL-1β,malondialdehyde（ MDA） in lung tissue. RESULTS Compared with the model group,AEPC（ 9. 0,4. 5 g·kg-1） produced significant inhibitory effects on acetic acid-induced permeability accentuation in the mice,and significantly reduced the levels of PGE2,TNF-α,IL-1β in the exudates,AEPC 9. 0 g·kg-1also reduced the contents of TNF-α,IL-1β,MDA in the lung tissue of rats,and AEPC of 4. 5 g·kg-1reduced the contents of IL-1β in the lung tissue. CONCLUSION AEPC has significant anti-inflammatory effects,which could be related with the inhibition of the generation of mediators of inflammation and its antioxidation.

关 键 词：川黄柏 醇提物 抗炎 前列腺素E2 肿瘤坏死因子-α 白细胞介素-1Β 丙二醛 机制 

分 类 号：R96[医药卫生—药理学]