左卡尼汀对老年冠心病合并充血性心力衰竭患者NT-proBNP和肌钙蛋白水平的影响  

Effect of L-carnitine Injection on NT-proBNP and Troponin Levels for Senile Patients with Coronary Heart Disease and Congestive Heart Failure

作　　者：曲鑫[1] 戴珩[2] 

机构地区：[1]中国医科大学附属盛京医院急诊科,辽宁沈阳110022 [2]中国医科大学附属盛京医院心内科,辽宁沈阳110022

出　　处：《贵阳医学院学报》2015年第5期490-492,共3页Journal of Guiyang Medical College

摘　　要：目的:探讨左卡尼丁注射液对老年冠心病合并充血性心力衰竭患者血浆N末端前脑钠肽(NT-pro BNP)及肌钙蛋白水平的影响。方法:冠心病合并充血性心力衰竭患者124例,随机均分为对照组与观察组,对照组患者给予常规治疗及安慰剂15 m L/次,2次/d,观察组患者给予常规治疗及左卡尼丁注射液15 m L/次,2次/d,分别测定两组患者治疗前和治疗第14天时血浆NT-pro BNP、肌钙蛋白及左室射血分数(LVEF),记录两组患者治疗第14天的临床疗效。结果:两组患者治疗后NT-pro BNP和肌钙蛋白水平均下降,LVEF升高,且观察组比对照组改善更明显,差异均有统计学意义(P<0.05);观察组患者的临床有效率显著高于对照组,差异有统计学意义(P<0.05)。结论:左卡尼汀注射液可能通过下调NT-pro BNP和肌钙蛋白水平改善老年冠心病合并充血性心力衰竭患者心衰指标,提高临床疗效。Objective： To investigate the clinical effect of L-carnitine injection on NT-pro BNP and troponin levels for senile patients with coronary heart disease and congestive heart failure. Methods： A total of 124 patients were divided into the control and experiment groups with equal numbers. The patients in control group received the common treatment and placebo of 15 mL per time,twice a day; the patients in experiment group received the common treatment and L-carnitine injection 15 mL per time,twice a day; then to compare the differences of NT-pro BNP and troponin levels,Left ventricular ejection fraction（ LVEF）,and the clinical effect 14 days later. Results： The NT-pro BNP and troponin levels of both groups were lower,and LVEF was higher than before,those of experiment group were all significantly improved than those of control group,differences were statistically significant（ P〈0. 05）.Clinical efficacy rate in experiment group was significantly higher（ P〈0. 05）. Conclusions： L-carnitine injection can improve the clinical effect for senile patients with coronary heart disease and congestive heart failure.

关 键 词：左卡尼汀 老年人 冠状动脉疾病 心力衰竭 充血性 肌钙蛋白 N末端前脑钠肽 

分 类 号：R541.61[医药卫生—心血管疾病]