造影剂剂量对冠心病患者PCI术后肾功能的影响  

Effect of Contrast Agents Dose on PCI Postoperative Renal Function of Patients with Coronary Heart Disease

作　　者：梁滨[1] 陈雨[2] 武宝林[2] 丁怀玉[2] 钟雷[2] 黄榕翀[2] 

机构地区：[1]大连市第三人民医院,辽宁大连116033 [2]大连医科大学附属第一医院,辽宁大连116011

出　　处：《贵阳医学院学报》2015年第5期533-535,541,共4页Journal of Guiyang Medical College

摘　　要：目的:探讨冠状动脉介入术(PCI)术中造影剂剂量对冠心病患者肾功能的影响。方法:选择行冠状动脉造影(CAG)和(或)PCI的患者265例,分为造影剂低剂量组(<150 m L)和高剂量组(>150 m L),比较两组患者注射造影剂前后肾小球滤过率差值(△GFR)及影响△GFR的因素,分析造影剂剂量与△GFR的相关性;根据患者基础GFR的不同分为2组(>90 m L/min组及60 m L/min^90 m L/min组),分析造影剂剂量对不同基础GFR患者△GFR的影响。结果:多因素线性回归分析显示低密度脂蛋白对△GFR有影响(P<0.05),造影剂剂量对△GFR作用显著(P<0.01);造影剂用量与△GFR相关系数r=0.32(P<0.05),造影剂剂量与GFR>90 m L/min组、GFR 60 m L/min^90 m L/min组△GFR的秩相关系数分别为0.312和0.334(P<0.05)。结论:造影剂剂量与△GFR间具有正相关关系,基础GFR越小,造影剂对GFR影响越大。Objective： To investigate the effect of contrast agent dose on renal function in patients with coronary heart diseases after PCI within seven days. Methods： A total of 265 patients with coronary heart diseases were performed angiogram and（ or） PCI,these patients were divided into two groups： low-dose group（ 〈150 mL） and high-dose group（〉 150 mL）. Comparing glomerulus filtration rate difference（ △GFR） of both groups before and after injection of contrast agents and influence factors,analyzing correlation between contrast agent dose and △GFR; all patients were divided into two groups by GFR（ 60 mL / min ～ 90 mL / min group and 〉90 mL / min group）. Investigating effects of dose of contrast agents on renal function in patients with coronary heart disease after PCI within the first seven days. Results： Multivariate linear regression analysis indicates that low-density lipoprotein had influence on △GFR（ P〈0. 05）,contrast agents dose has significant influence on △GFR（ P〈0. 01）; the correlation coefficient of contrast agents dose and △GFR was r = 0. 32（ P〈0. 05）. Correlation coefficient between contrast agents dose and GFR〉 90 mL / min group,GFR 60 mL / min ～90 mL / min group △GFR are 0. 312 and 0. 334（ P〈0. 05） respectively. Conclusions： The dose of contrast agents shows positive relationship with △GFR,with lower level of GFR,influence of contrast agents on GFR tends to be greater.

关 键 词：冠状血管造影术 选影剂 肾功能 肾小球滤过率 

分 类 号：R541.4[医药卫生—心血管疾病]