6-O-取代红霉素衍生物的研究进展  

Development in 6-O-Substituted Erythromycin Derivatives

作　　者：赵娜[1] 毕小玲[1] 

机构地区：[1]中国药科大学药物化学教研室,江苏南京210009

出　　处：《药学进展》2015年第3期179-187,共9页Progress in Pharmaceutical Sciences

摘　　要：大环内酯类抗生素广泛用于治疗呼吸道感染,但日益泛滥的大环内酯耐药菌正影响着公众的健康。为了解决这一问题,科研工作者对大环内酯类化合物进行了大量的结构修饰。综述近年来对红霉素衍生物C6位进行的结构改造及对其生物活性的影响。Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections. However, the increasing prevalence of macrolide-resistant pathogens poses a serious risk to public health. To overcome the issue of drug resistance, numerous modifications have been made on macrolides. The recent development in structural modifications on C6 of erythromycin derivatives and the impact to biological activity was reviewed.

关 键 词：大环内酯 红霉素 6-O-取代 C6-氨基甲酸酯 6-O-烷基 

分 类 号：R978.1[医药卫生—药品]