我院伏立康唑致不良反应30例报告分析  

Analysis of 30 Cases of Adverse Drug Reaction Reports Induced by Voriconazole in Our Hospital

作　　者：田洁[1] 彭菲[1] 张贵宁 陈小燕[1] 王金平[1] 吴建龙[1] 

机构地区：[1]深圳市第二人民医院药学部临床药学科,广东深圳518035 [2]深圳市眼科医院药剂科,广东深圳518040

出　　处：《中国药房》2015年第17期2350-2352,共3页China Pharmacy

基　　金：深圳市科技计划项目(No.JCYJ20140414170821258)

摘　　要：目的:了解我院应用伏立康唑所致药品不良反应(ADR)发生的特点及一般规律,为临床合理用药提供参考。方法:通过广东省ADR管理平台,在ADR报表统计模块中,以通用名称"伏立康唑"对我院2007-2014年的数据进行检索,导出Excel报表。对伏立康唑致ADR患者的性别、年龄、用药方案(包括给药剂量、途径和天数)、ADR名称、临床表现和处理等进行统计、分析。结果:所收集的30例伏立康唑所致ADR报告中,ADR以消化系统、精神与行为障碍、神经系统和眼睛及其附属器官等损害为主,占77.78%;20例ADR为静脉滴注给药;30例ADR平均发生时间为4.65 d,其中≤1 d发生的有11例;所有的ADR均治愈,无遗留后遗症或死亡。结论:临床应用伏立康唑时,应注意观察ADR的发生,尤其是联用与伏立康唑有相互作用的药物时,更要注意药物剂量调整和ADR监测。有条件时可进行伏立康唑的血药浓度监测,确保用药安全。OBJECTIVE： To evaluate and analyze the reports of adverse drug reaction （ADR） induced by voriconazole in our hospital and provide reference for the clinical rational use of drug. METHODS： According to the Guangdong Province ADR Management Platform, ADR report statistic modules in our hospital from 2007 to 2014 were retrieved to collect the data by Excel with the combination keyword of ＂voriconazole＂. Then data was saved and statistically analyzed on the sex, age, medication （dosage, administration route and course）, ADR names, clinical manifestations and treatment, etc. RESULTS： The 30 ADR reports induced by voriconazole were mainly the digestive system, mental and behavioral disorders, nervous system, vision system and appendages damage （77.78%）, 20 cases were administrated via intravenous in fusion; the mean occurance time of ADR were 4.65 days, 11 cases were 〈 1 d. All the ADR cases were cured with no sequela or death. CONCLUSIONS： The incidence of ADR should be noticed when voriconazole is administrated, and attention should be paid to the dosage adjustment and ADR monitoring, especially combined application of interaction drugs. The serum concentration of voriconazole should be monitored if necessary to ensure the medication safety.

关 键 词：伏立康唑 药品不良反应 血药浓度监测 

分 类 号：R969.3[医药卫生—药理学]