病原体感染对宿主DNA损伤修复机制的影响  

The impact of pathogens on DNA damage and repair pathways

作　　者：汪琦[1] 

机构地区：[1]广东药学院基础学院病原生物学与免疫学系,广东广州510006

出　　处：《中国病原生物学杂志》2015年第4期381-383,共3页Journal of Pathogen Biology

摘　　要：基因组的完整和稳定是机体生存的基础,基因组异常导致肿瘤、免疫缺陷等多种疾病。DNA损伤修复是维持核基因组完整和稳定的首要机制,机体通过DNA损伤信号传导,激活相应的修复途径,如MMR、BER、NER、SSER、DSER等,以保持基因组的稳定。近年研究发现,病原体感染可改变、破坏或操纵宿主DNA损伤修复途径,本文将综述细菌、病毒、寄生虫等病原体感染,对宿主DNA损伤修复机制的直接影响。The integrity and stability of an organism＇s genome is the basis for its survival. Genomic abnormalities con- tribute to various diseases including tumors and immunodeficiency. DNA damage and repair （DDR） mechanisms have e- volved as a key way to maintain the integrity and stability of the genome. Repair pathways are activated through DNA damage signaling. DDR mechanisms include mismatch repair （MMR）, base excision repair （BER）, nucleotide excision repair （NER）, single-stranded break repair （SSBR）, and double-stranded break repair （DSBR）. Pathogens can alter, subvert, or manipulate the DDR pathways. This article discusses the direct impact of pathogens including viruses, bacte- ria, and parasites on DDR pathways.

关 键 词：病原体 DNA损伤修复 基因组完整和稳定 综述 

分 类 号：R37[医药卫生—病原生物学]