头穴透刺对脑出血大鼠脑含水量及AQP-4表达研究  

Experimental Study on Scalp Point-to-point for Water Content of Brain and Expression of AQP-4 in Rats with Cerebral Hemorrhage

作　　者：李雪岩[1] 师帅[1] 李德韬[2] 包瑞[1] 

机构地区：[1]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150001 [2]大庆油田总医院脑血管医院,黑龙江大庆163000

出　　处：《针灸临床杂志》2015年第5期70-72,共3页Journal of Clinical Acupuncture and Moxibustion

基　　金：黑龙江省教育厅科学技术研究项目;编号:12531649

摘　　要：目的:探讨针刺对脑出血的调控机制。方法:96只大鼠随机分为3组(对照组、模型组、针刺组),每组分4个时间点(12 h、24 h、3天、7天),每个时间点8只大鼠,模型成功6 h后给予针刺百会透悬厘治疗,于12 h、24 h、3天、7天时间取材;然后测定脑含水量及评定AQP-4表达。结果:针刺有降低脑含水量作用,对AQP-4表达有抑制作用,针刺组优于其他两组(P<0.05)。结论:百会透刺悬厘治疗能降低脑含水量,控制脑水肿,促进脑出血恢复;抑制AQP-4表达,进而保护脑受损的神经元。Objective：To discuss the regulative mechanisms of acupuncture for treating cerebral hemorrhage. Methods：96 rats were randomized into 3 groups（ a normal group,a model group and an experimental group） and every group was divided into 4 time points with 8 rats.With successfully modeling after 6 hours give acu-puncture at Xuanli（ GB6） and Baihui（ GV20） treatment and collect data after 12 h,24 h,3 d and 7 d.Measure water content of brain and assess the expression of AQP-4.Results：Acupuncture could treat cerebral edema and inhibit expression of AQP-4 and the experimental group had a better effect than other groups （P〈0.05）. Conclusion：Acupuncture at Baihui-to-Xuanli can reduce water content of brain and protect damaged neu-rons.

关 键 词：AQP-4 脑含水量 脑出血 大鼠 百会 悬厘 透刺 

分 类 号：R246.6[医药卫生—针灸推拿学]