5750例孕中期孕妇羊水染色体核型检测结果分析  

Analysis of 5750 cases of amniotic karyotype detection results

作　　者：马光娟 唐静 刘璇 杨艳 王丽霞 刘宁 郭晓丽 马晓蓉 代文成 

机构地区：[1]新疆维吾尔自治区妇幼保健院产前诊断中心,乌鲁木齐830001

出　　处：《中国优生与遗传杂志》2015年第5期47-49,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的对我院2009年至2014年6月,5750例孕中期各种高危因素做羊水染色体核型检出的结果进行分析。方法在无菌条件下,由B超定位抽取羊水细胞培养,常规收获,G显带,核型分析后进行统计分析。结果共检出异常核型208例,异常检出率为3.62%(208/5750),其中染色体数目异常124例,占染色体异常核型百分比为59.61%,结构异常84例,占染色体异常核型百分比40.4%。非整体核型仍然以21三体综合征发病率最高,占所有染色体异常的28.36%,结论染色体核型检出对具有不同产前诊断指征的孕妇行羊膜腔穿刺术,指导临床干预具有重要的价值。Objective： During 2009 to 2014 June, We have detected 5750 cases of amniotic fluid karyotype of all kinds high-risk factor, and analyze them. Methods： Under sterile conditions, following B ultrasound localization, We extract the amniotic fluid to cultured, conventional harvest, G banding karyotype analysis, and statistical analysis after.; Results： There were 208 cases of abnormal karyotype, The abnormal rate was 3.62% （208/5750） , the number of chromosome abnormality is 124, accounting for 59.61% percentage of abnormal karyotype of chromosomep; Structural abnormalities 84 cases, accounting for 40.4% of the percentage of abnormal karyotype of chromosome. Non euploid karyotype still with trisomy 21 had the highest incidence, accounting for all the abnormality of chromosome 28.36%. Conclusions： Chromosomal karyotype detection with different indications for prenatal diagnosis of pregnant women underwent amniocentesis, guide clinical intervention has important value.

关 键 词：羊水细胞 染色体核型 遗传咨询 

分 类 号：R714.55[医药卫生—妇产科学]