EmbryoGlue应用于冷冻复苏胚胎移植对种植率及妊娠结局的影响  

Influence of Embryo Glue on the implantation of embryo and pregnancy outcome in freezing embryo transfer

作　　者：韩瑞刚[1] 王斌[1] 张娥[1] 金丹[1] 崔丽君[1] 朱亮[1] 

机构地区：[1]解放军第306医院生殖中心,北京100101

出　　处：《中国优生与遗传杂志》2015年第5期101-103,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的研究Embryo Glue作为移植液对IVF技术中FET种植率及妊娠结局的影响。方法病例来自解放军第306医院生殖医学中心2013年1月至2014年6月间就诊的FET患者,共计351例。冷冻胚胎均为D3胚胎,冷冻解冻液均采用Vitrolife G5系列试剂。患者共分为2组,实验组164例,以Embryo Glue作为移植液;对照组187例,以常规G-2作为移植液。同时,每组根据有无优胚,又分为优胚亚组和非优胚亚组。比较两组及亚组间种植率及妊娠率。结果 (1)女方年龄、IVF/ICSI比例、不孕原因、既往失败周期数等因素,两组间无统计学差异。(2)实验组种植率明显高于对照组[23.2%(91/392)vs 14.9%(68/454),P<0.05]。其中实验组优胚亚组及非优胚亚组种植率均明显高于对照组相应亚组[优胚亚组75/280(26.7%)vs 59/302(19.5%),P>0.05;非优胚亚组[16/112(14.3%)vs 9/152(5.9%),P<0.05]。(3)实验组妊娠率明显高于对照组[42.7%(70/164)vs 30.5%(57/187),P<0.05]。其中实验组优胚亚组与对照组优胚亚组间妊娠无明显差异[45.4%(54/119)vs 35.8%(48/134),P>0.05],而实验组非优胚亚组妊娠率明显高于对照组非优胚亚组[35.5%(16/45)vs 16.9%(9/53),P<0.05]。(4)多胎率实验组与对照组未见明显差异[18/70(25.7%)vs 10/57(17.5%),P>0.05]。结论 Embryo Glue有助于提高FET中种植率和妊娠率,尤其是移植非优质胚胎时。Objective： To study the influence of EmbryoGlue on the implantation of embryo and pregnancy outcome freezing embryo transfer （FET） . Methods： From January 2013 to June 2014, 351 infertile patients in Reproductive Medical Center of The 306th Hospital of the PLA, who underwent freezing embryo transfer （FET） were enrolled. All patients embryos were cultured with Vitrolife G5 series, and freezed in D3. All patients were divided into two groups, including 164 cases used EmbryoGlue as the embryo transfer medium in experimental group and 187 cases used G-2 as embryo transfer medium in control group.Meanwhile, every group were divided into high quality embryos subgroup and low quality embryos subgroup, according to whether containing at least one high quality embryo. Pregnancy outcome were compared between two groups and subgroups. Results： （1） The female age, IVF/ICSI constituent ratio, previous failure cycles and infertile factors of patients did not show statistical difference between experimental group and control group （P〉0.05） . （2） The implantation rate of women in experimental group increased significantly compared with the control group[23.2% （91/392） vs 14.9% （68/454） , P〈0.05]. The implantation rate of women in two subugroups of experimental group increased significantly compared with the subgroups of control group[high quality subgroup 26.7% （75/280） vs 19.5% （59/302） , P〉0.05] low quality subgroup14.3% （16/112） vs 5.9% （9/152） , P〈0.05]. （3） Clinical pregnancy rate in experimental group increased significantly compared with the control group[42.7% （70/164） vs 30.5% （57/187） , P〈0.05]. In high quality subgroups of two groups, there were no signifacant difference in clinical pregnancy rate[45.4% （54/119） vs 35.8% （48/134） , P〉0.05]. In low quality subgroup of experimental group, clinical pregnancy rate increased significantly compared with low quality subgroupof control group[35.5% （16/45） vs 16.9% （9/53） , P〈0.05]. �

关 键 词：冷冻 胚胎移植 种植率 妊娠率 

分 类 号：R714.8[医药卫生—妇产科学]