不同精子来源及受精方式对胚胎冻融结局的影响  

A comparison of clinical outcome after cryopreservation of embryos obtained from in-vitro fertilization or intracytoplasmic sperm injection by surgically retrieved or ejaculated sperm

作　　者：李楠 唐永梅 唐妮 韦立红 梁明明 韦继红 

机构地区：[1]广西柳州市妇幼保健院生殖健康助孕中心,广西柳州545001

出　　处：《中国优生与遗传杂志》2015年第5期109-111,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨常规体外受精(IVF)、精液精子与穿刺后精子卵胞浆内单精子注射(ICSI)对胚胎冻融结局的影响。方法分析我中心2013年1月至2013年12月间行胚胎冻融移植周期的临床妊娠结局,其中IVF周期1479,ICSI周期258,早期补救52例;来源于精液精子组105个周期,行穿刺后精子组33个周期。结果 IVF组、ICSI组与早期补救ICSI组间的复苏胚胎存活率相比无差异(96.5%、95.0%vs 99.0,P>0.05);三组之间种植率、妊娠率相比也无统计学差异(27.7%、25.3%vs 35.1%;41.0%、39.5%vs 46.2%,P>0.05)。精液精子组与穿刺精子组的复苏胚胎存活率、种植率和妊娠率之间差异不显著(P>0.05)。结论 ICSI及穿刺后精子行ICSI胚胎其冻融后的存活率和妊娠率与常规IVF之间无显著差异。Objective： A study of clinical outcome after cryopreservation of embryos obtained from in-vitro fertilization （IVF） or intra-cytoplasmic sperm injection （ICSI） by surgically retrieved. Methods： Frozen embryo transfer cycles （FET） between January 2013 and December 2013 were included. 1479 cycles were derived from oocytes fertilized by IVF, 258 cycles were derived from oocytes fertilized by ICSI and 52 cycles were derived from oocytes fertilized by rescue ICSI. The clinical outcome was compared. Results- The embryo survival rates were similar between three groups （96.51% ~ 95.00% vs 99.00, P〉0.05） . There was no significant difference in pregnancy rates （41.0%~ 39.5% vs 46.2%） and implantation rates （27.71%, 25.3% vs 35.1% ） between the IVF / ICSI and Rescue ICSI cycles groups respectively. There was no significant difference in recovery rate, implantation rate and clinical pregnancy rate between ejaculated sperm group and testicular sperm group （P〉0.05） . Conclusion： ICSI does not have an adverse impact on the survival and development potential of cryopreserved and thawed embryos. ICSI is mainly applied for patients with primary infertility and infertility induced by male factor.

关 键 词：辅助生殖技术 卵胞浆内单精子注射 体外受精 玻璃化冷冻 精子 睾丸精 

分 类 号：R714.8[医药卫生—妇产科学]