多囊卵巢综合征患者IVF-ET后早期自然流产的相关因素分析  

The analysis of early pregnancy loss in women with polycystic ovarian syndrome after in vitro fertilization-embryo transfer

作　　者：聂明月 杨晓葵[1] 

机构地区：[1]首都医科大学附属北京妇产医院生殖医学科,北京100026

出　　处：《中国优生与遗传杂志》2015年第5期115-117,124,共4页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金项目(81170542);北京市卫生系统高层次人才培养项目(2011-3-071);首都医科大学附属北京妇产医院学科带头人项目(2013-2)

摘　　要：目的回顾性分析多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者行体外受精/卵母细胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)助孕后发生早期自然流产的危险因素。方法选择2010年1月至2013年9月于首都医科大学附属北京妇产医院生殖中心因输卵管因素和/或男方因素进行IVF/ICSI-ET助孕并成功妊娠的PCOS患者共190例,分为自然流产组和分娩组,对比两组患者的基础内分泌水平及IVF结局,分析早期自然流产发生的高危因素。结果流产组的年龄、体重指数(body mass index,BMI)、基础黄体生成素(luteinizing hormone,LH)和基础睾酮(testosterone,T)水平显著高于分娩组(P<0.05);经Logistic回归分析发现年龄和BMI与自然流产的发生密切相关;两组窦卵泡数,HCG日激素水平、促性腺激素用药情况,获卵数,优胚率等均无统计学差异(P>0.05)。结论年龄、BMI是PCOS患者在IVF助孕后发生早期自然流产的危险因素,而内分泌因素与PCOS患者早期自然流产的关系尚需扩大样本进一步研究。Objective： To retrospectively analyze the risk factors of pregnancy loss in patients with polycystic ovarian syndrome （PCOS） after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer （IVF/ICSI-ET） . Method： 190 PCOS women undergoing IVF/ICSI-ET therapy due to tubal and/or male factors from January 2010 to September 2013 were analyzed. All patients were divided into two groups, including the miscarried PCOS group and the delivered PCOS group. The basal hormone levels and IVF outcomes were compared between the two groups in order to explore the risk factors associated with early pregnancy loss among PCOS patients. Results： In miscarried PCOS group, the age, body mass index （BMI） , basal luteinizing hormone （LH） and basal testosterone （T） were significantly higher compared with the delivered group （P〈0.05） . Multiple factors Logistic regression analysis demonstrated that age and BMI were in correlation with PCOS pregnancy loss. There was no significant difference in antral follicle count （AFC） , HCG day hormone levels, usage of gonadotropins, retrieved oocytes and high quality embryos （P〉0.05） . Conclusion： Age and BMI are risk factors of pregnancy loss in patients with PCOS after IVF- ET. The relationship between endocrine hormone and PCOS pregnancy loss needs to be further studied.

关 键 词：多囊卵巢综合征 体外受精-胚胎移植 危险因素 自然流产 

分 类 号：R714.8[医药卫生—妇产科学]