高中心动脉脉压水平与慢性腹膜透析病人的心血管疾病相关  

High central pulse pressure level is associated with cardiovascular disease in patients receiving maintenance peritoneal dialysis

作　　者：杨小兵[1] 郭东风 蒋建平[1] 

机构地区：[1]南方医科大学南方医院肾内科,广东广州510515 [2]岳阳市第一人民医院肾内科,湖南岳阳414000

出　　处：《南方医科大学学报》2015年第5期716-719,共4页Journal of Southern Medical University

基　　金：国家自然科学基金(81470995);广东省自然科学基金(2014A030313345)~~

摘　　要：目的了解慢性腹膜透析病人的中心动脉脉压水平,分析其与心血管疾病(CVD)的关系。方法单中心横断面研究,共纳入234例维持性腹膜透析病人(均接受腹膜透析3月以上)。采用Sphygmo Cor无创主动脉脉波分析仪检测病人的中心动脉收缩压和舒张压,脉压=收缩压-舒张压。CVD定义为临床确诊的缺血性心脏病,心力衰竭,脑卒中和外周血管性疾病。结果有CVD的腹膜透析病人中心动脉脉压水平显著高于无CVD者(51.7±22.5 mm Hg vs 43.7±17.8 mm Hg,P=0.004),而肱动脉脉压在两组病人间无显著差异(66.7±25.3 mm Hg vs 61.9±19.7 mm Hg,P=0.106)。多因素Logistic回归分析后,中心动脉脉压仍独立与CVD相关(校正后OR 1.33,95%置信区间1.01-1.73,P=0.04)。结论高中心动脉脉压水平与慢性腹膜透析病人CVD相关。Objective To evaluate the association between central pulse pressure level and cardiovascular diseases （CVD） in patients receiving maintenance peritoneal dialysis. Methods This cross-sectional study was conducted in 234 patients on maintenance peritoneal dialysis. Central pulse pressure levels were measured using a SphygmoCor analyzer, and cardiovascular diseases were defined as diagnosed ischemic heart disease, heart failure, stroke or peripheral vascular disease. Results The central pulse pressure levels of patients with CVD were significantly higher than those without CVD （51.7±22.5 vs 43.7 ± 17.8 mmHg, P=0.004）, while the brachial pulse pressure levels were comparable between the two patient groups. After adjusting for brachial pulse pressure and other relevant risk factors, central pulse pressure level was found to independently associate with CVD （adjusted OR=1.33, 95%CI 1.01-1.73, P=0.04 ）. Conclusion High central pulse pressure level may serve as a risk factor for CVD in patients on maintenance peritoneal dialysis.

关 键 词：中心动脉脉压 心血管疾病 腹膜透析 

分 类 号：R459.5[医药卫生—治疗学]