糖尿病胃肠病变动物模型的建立与评估  

Establishment and evaluation of animal models of diabetic gastroparesis

作　　者：田佳星[1,2] 李敏[1] 甄仲[1] 李君玲[2] 曹洋[2] 闫韶花[1] 仝小林[1] 

机构地区：[1]中国中医科学院广安门医院内分泌科,北京市100053 [2]北京中医药大学研究生院,北京市100029

出　　处：《世界华人消化杂志》2015年第13期2091-2097,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81173259~~

摘　　要：糖尿病胃肠病变是糖尿病常见的并发症之一,近年来发病率逐年提高,引起人们的普遍关注,成功有效地建立糖尿病胃肠病变动物模型,对于探索其发病机制及治疗手段是十分必要的,然而目前糖尿病胃肠病变模型的建立方法及评估手段尚无完善统一的标准,缺乏系统化的评述及指导.我们通过检索近年来国内外学者在糖尿病胃肠病变方面开展的基础实验研究,总结概括了实验者所运用的模型建立方法及评估手段.模型建立方法分别从1型糖尿病胃肠病变动物模型、2型糖尿病胃肠病变动物模型、自发性糖尿病胃肠病变动物模型及其他动物模型的应用展开论述;模型的评估方法具体包括13C-辛酸呼气试验、单光子发射计算机断层成像术、酚红液体测定法、小肠推进率测定和胃运动曲线的测定.结合文献报道,我们将对各方法存在相应的优势与不足作以进一步的论述,对于该病的基础研究具有一定的启示,为更深入地干预防治本病提供理论依据.The incidence of diabetic gastrointestinal disease, one of the most common complication of diabetes, is growing in recent years.Establishing an adequate animal model of diabetic gastrointestinal disease could effectively lay a solid foundation for the exploration of its mechanism and treatment. The rate of gastric emptying in diabetic gastrointestinal disease varies from acceleration to deceleration in different stages, and there is a lack of objective indicators to evaluate it. The establishment and evaluation of animals with diabetic gastrointestinal disease is still in the exploration stage. In this paper we summarize the establishment and evaluation of animal models of diabetic gastrointestinal disease. We compare the advantages and disadvantages of these animal models, in order to provide a reference for further study and treatment of this disease.

关 键 词：糖尿病胃肠病变 动物模型 评估 

分 类 号：R587.2[医药卫生—内分泌] R-332[医药卫生—内科学]