血浆脂蛋白a、高敏C反应蛋白、脑钠肽水平与冠状动脉病变程度的相关性研究  

The correlation between the levels of the plasma lipoprotein( a),high sensitive C-reactive protein and brain natriuretic peptide with the severity of coronary artery disease

作　　者：牛海军[1] 吴桥[1] 江荣炎[1] 卜令同[1] 

机构地区：[1]安徽省亳州市人民医院内科,236800

出　　处：《蚌埠医学院学报》2015年第5期629-632,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨血浆脂蛋白a[Lp(a)]、高敏C反应蛋白(hs-CRP)、脑钠肽(BNP)水平与冠状动脉病变程度的相关性。方法:将216例行冠状动脉造影患者根据造影结果分为冠心病组129例(包括单支病变组35例、双支病变组40例和三支病变组54例)和对照组87例。分别检测各组患者血浆Lp(a)、hs-CRP、BNP水平,并分析其与冠状动脉病变支数及Gensini评分的相关性。结果:冠心病组患者血浆Lp(a)、hs-CRP和BNP水平均明显高于对照组(P<0.01)。不同病变支数各组血浆Lp(a)、hs-CRP、BNP水平差异均有统计学意义,其中三支病变组均明显高于对照组及单支病变组(P<0.01)。随着Gensini评分升高,血浆Lp(a)、hs-CRP和BNP水平也随之升高(P<0.01)。冠心病组血浆Lp(a)、hs-CRP和BNP水平与冠状动脉病变支数及冠状动脉Gensini评分均呈正相关关系(P<0.01)。结论:联合检测血浆Lp(a)、hs-CRP、BNP水平对判断冠状动脉病变程度具有指导意义。Objective：To explore the correlation between the levels of the plasma lipoprotein（a） [ Lp（a） ] , high sensitive C-reactive protein（hs-CRP） and brain natriuretic peptide （BNP） with the severity of coronary artery disease （CAD）. Methods：According to the results of coronary angiography,216 patients were divided into the CAD group（216 cases） and control group（87 cases） ,and the CAD group were subdivided into the single-vessel disease group（35 cases）, double-vessel disease group（40 cases） and three-vessel disease group（54 cases）. The levels of the plasma Lp （a）, hs-CRP and BNP in all groups were detected, and the correlations of whose with coronary lesion vessels and Gensini scores were analyzed. Results： The levels of Lp （a） , hs-CRP and BNP in CAD group were significantly higher than those in control group（ P 〈 0.01 ）. The differences of the levels of Lp（a） , hs-CRP and BNP in different vessels disease group were statistically significant （P 〈 0.01 ） , and the levels of Lp （a） , hs-CRP and BNP in three-vessel disease group were significantly higher than those in control group and single-vessel disease group （ P 〈 0.01 ）. With the increasing of Gensini score, the levels of plasma Lp （ a）, hs-CRP and BNP increased （ P 〈 0.01 ）. There was a positive correlation between the levels of Lp （ a）, hs-CRP and BNP with coronary lesion vessels and Gensini scores（ P 〈 0.01 ）. Conclusions：The combined detection of the levels of plasma Lp （a） ,hs-CRP and BNP has an important significance in judging the severity of coronary artery disease.

关 键 词：冠心病 脂蛋白A 高敏C反应蛋白 脑钠肽 

分 类 号：R541.4[医药卫生—心血管疾病]