糖尿病患者人巨细胞病毒、柯萨奇B组病毒和胰岛细胞抗体、谷氨酸脱羧酶抗体及空腹血糖水平的变化及其临床意义  

The combined detection of HCMV,CVB antibody,ICA,GADA and FPG in patients with T1DM and T2DM

作　　者：赵长新[1] 温江涛[1] 李世宝[1] 高云明[2] 闻海霞[2] 周彦[1] 

机构地区：[1]连云港市第二人民医院检验科,222002 [2]连云港市第二人民医院内分泌科,222002

出　　处：《中国糖尿病杂志》2015年第6期505-508,共4页Chinese Journal of Diabetes

基　　金：蚌埠医学院科研基金项目(BYKY1290NF)

摘　　要：目的探讨人巨细胞病毒（HCMV）、柯萨奇B组病毒（CVB）及ICA、GADAb、FPG检测多因素与糖尿病的关系。方法选取我院2011~2013年住院或门诊糖尿病患者100例,其中,T1DM（T1DM组）、T2DM（T2DM组）患者各50例。另选取健康对照（NC组）者50名。检测各组ICA、GADAb、人巨细胞病毒lgM抗体（HCMV-lgM）、人巨细胞病毒IgG抗体（HCMV-IgG）、柯萨奇B组病毒IgM抗体（CVB-IgM）及FPG水平。结果抗HCMV-IgM、抗HCMV-IgG、抗CVB-IgM、ICA、GADA阳性例数（阳性率）T1DM组分别为16（32%）、36（72%）、22（44%）、29（58%）、13（26%）,T2DM组分别为3（6%）、21（42%）、4（8%）、12（24%）、1（2%）,NC组分别为1（2%）、11（22%）、1（2%）、1（2%）、0（0%）（P〈0.05）。与NC组比较,T2DM组抗HCMV-IgG、ICA抗体检测阳性结果差异有统计学意义（P〈0.05）。3组FPG水平比较差异有统计学意义（P〈0.05）。结论联合检测HCMV、CVB抗体及ICA、GADAb、FPG对糖尿病患者的诊疗具有重要价值。Objective To explore the diagnostic significance of combined detection of HCMV,CVB antibody,ICA,GADA and FBG in patients with T1 DM and T2 DM.Methods A total of 100 inpatients or outpatients with diabetes mellitus admitted to our hospitalfrom 2011 to 2013 were selected as study subjects.50 patients in T1 DM group and 50 patients in T2 DM group and 50 healthy people as normal control were selected in the study.ICA was detected with indirect immunofluorescence method,GADAb,HCMV-lgM,HCMV-IgG,CVB-IgM were determined with ELISA method and FPG was determined with AU5800 biochemical analyzer.Results The positive cases number（positive rate）in T1 DM,T2DM group and healthy control group were 16（32%）,3（6%）,1（2%）for anti-HCMV-IgM;36（72%）,21（42%）,11（22%）for anti-HCMV-IgG;22（44%）,4（8%）,1（2%）for anti-CVB-IgM;29（58%）,12（24%）and 1（2%）for ICA;13（26%）,1（2%）and 0（0%）GADA,（all P 〈0.05）respectively.Comparison between T2 DM group and healthy control group,the difference inpositiveresults of antiHCMV-IgG and ICA antibody were statistically significant（P〈0.05）.There were statistical significances for FPG among the three groups（P〈0.05）.Conclusion Joint detection of HCMV,CVB antibody,ICA,GADAb,and FPG is of great value to the diagnosis and treatment T1 DM and T2 DM.

关 键 词：糖尿病 1型 糖尿病 2型 人巨细胞病毒 柯萨奇B组病毒 

分 类 号：R587.1[医药卫生—内分泌]