成人隐匿性自身免疫性糖尿病患者晚餐前高血糖与胰岛β细胞功能的相关性研究  

Relationship between hyperglycemia before the supper and the isletβcell function in patients with latent autoimmune diabetes in adults

作　　者：赵建林[1] 王林栋[1] 陈玉凤[1] 郭献山[1] 吴苏豫[1] 耿秀琴[1] 

机构地区：[1]新乡市中心医院内分泌科,453000

出　　处：《中国糖尿病杂志》2015年第6期509-511,共3页Chinese Journal of Diabetes

摘　　要：目的了解成人隐匿性自身免疫性糖尿病(LADA)患者晚餐前高血糖与胰岛β细胞功能及皮质醇水平的相关性。方法选取合并晚餐前高血糖LADA患者32例为试验组,不合并晚餐前高血糖LADA患者39例为对照1组,T2DM患者30例为对照2组。检测各组FPG、FC-P、HbA1c及皮质醇水平,采用改良HOMA公式计算胰岛素分泌指数(HOMA-islet),评价胰岛β细胞功能。结果试验组HOMA-islet低于对照1组和对照2组[(17.1±8.9)vs(35.1±16.5)vs(69.5±27.1),P<0.05],但各组皮质醇水平比较,差异无统计学意义(P>0.05)。Logistic回归分析结果显示,晚餐前高血糖与HbA1c、BMI及HOMA-islet有相关性(OR=0.31、5.53、1.31,P<0.05),与皮质醇水平无相关性(P>0.05)。结论晚餐前高血糖是提示胰岛β细胞功能损伤的指标之一,其与皮质醇水平无关。Objective To investigate the relationship between hyperglycemia before the supper and the isletβcell function in patients with latent autoimmune diabetes in adults（LADA）.Methods 32 LADA patients with the hyperglycemia before the supper（Experiment group）,and 39 without the hyperglycemia before the supper（Control 1group）,and 30 T2 DM patients（Control 2 group）were enrolled.The FPG,FC-P,HbA1 c and plasma cortisol were tested.The HOMA-islet was calculated by using the modified HOMA formula to evaluate the islet beta cell function.Results The result of HOMA-islet was lower in experiment group than in control 1and control 2groups[（17.1±8.9）vs（35.1±16.5）vs（69.5±27.1）,P〈0.05],but the plasma cortisol levels were no differences among three groups.Logistic regression analysis showed that HbA1 c,BMI and HOMA-islet was associated with the hyperglycemia before supper（OR=0.31,5.53,1.31,all P〈0.05）,and not with plasma cortisol levels（P〉0.05）.Conclusion The hyperglycemia before the supper may be an index of the isletβcell failure,and it is not related to the change of plasma cortisol levels.

关 键 词：成人隐匿性自身免疫性糖尿病 晚餐前高血糖 胰岛Β细胞功能 皮质醇 

分 类 号：R587.1[医药卫生—内分泌]