每日口服10mg阿托伐他汀对原发性高血压合并糖耐量减低患者炎症因子水平影响的临床观察  

Effects of Atorvastatin 10 mg daily on inflammatory cytokines in hypertension patients with impaired glucose tolerance

作　　者：单红英[1] 张微[1] 梁瑞景 白静 邱冬梅 李海涛[5] 裴文杰[1] 马艳玲[6] 

机构地区：[1]秦皇岛市第三医院心内科,066100 [2]石家庄市老年病医院心内科 [3]秦皇岛市抚宁县人民医院放疗科 [4]秦皇岛市山海关人民医院心内科 [5]唐山市华北煤炭医学院附属医院心内科 [6]秦皇岛市第三医院儿科,066100

出　　处：《中国糖尿病杂志》2015年第6期543-545,共3页Chinese Journal of Diabetes

摘　　要：目的观察每日口服10mg阿托伐他汀对原发性高血压(EH)合并IGT患者炎症因子水平的影响。方法 36例EH合并IGT患者(EH+IGT组)口服阿托伐他汀10mg,1次/晚。另选择36例体检者作为对照(NC)组。检测两组FPG、2hPG、胰岛素抵抗指数(HOMA-IR)及血清炎症因子水平的变化。结果 EH+IGT组均完成试验。口服10 mg阿托伐他汀治疗8周BP、2hPG、HOMA-IR、TNF-α及IL-6均下降[BP(159.71±12.25)/(98.67±12.06)vs(131.89±10.72)/(81.76±9.03)mmHg;2hPG(8.39±0.65)vs(6.76±1.19)mmol/L;HOMA-IR(3.11±1.95)vs(2.30±1.25);TNF-α(32.11±5.36)vs(24.29±4.57)ng/L;IL-6(112.37±24.48)vs(70.47±13.30)ng/L](P<0.01)。结论每日口服10mg阿托伐他汀可降低EH合并IGT患者的血清炎症因子水平。Objective To study the effects of Atorvastatin 10 mg daily on plasma inflammatory cytokines in hypertension patients with impaired glucose tolerance.Methods A total of 36 EH patients with IGT recieved Atorvastatin 10 mg,qn.36 healthy adults served as controls.The levels of fasting blood glucose,postprandial-2-hour blood glucose,HOMA-IR,inflammatory cytokines of each group were tested before and after treatment.Results All the participants in EH ＋IGT group finished the study.Compared with control group,BP,2hPG,HOMA-IR,TNF-αand IL-6 were decreased significantly[BP（159.71±12.25）/（98.67±12.06）vs（131.89±10.72）/（81.76±9.03）mmHg];2hPG（8.39±0.65）vs（6.76±1.19）mmol/L;HOMA-IR（3.11±1.95）vs（2.30±1.25）;TNF-α（32.11±5.36）vs（24.29±4.57）ng/L;IL-6（112.37±24.48）vs（70.47±13.30）ng/L]（P〈0.01）.Conclusion Atorvastatin 10 mg daily could decrease the level of inflammatory cytokines in hypertension patients with impaired glucose tolerance.

关 键 词：阿托伐他汀 原发性高血压 糖耐量异常 肿瘤坏死因子-Α 白细胞介素-6 

分 类 号：R544.11[医药卫生—心血管疾病]