高密度脂蛋白组成部分中的不同亚类对冠状动脉狭窄程度影响的相关性研究  

The correlation study of the impact of the different subclasses in high-density lipoprotein components on the severity of coronary artery stenosis

作　　者：杨宁 胡立群 李红旗 章琦 

机构地区：[1]安徽医科大学附属省立医院老年心内科安徽省心血管病研究所,安徽合肥230001

出　　处：《安徽医药》2015年第6期1091-1094,共4页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省科技厅年度科研计划项目(No 10021303079)

摘　　要：目的探讨冠脉造影患者高密度脂蛋白(high-density lipoprotein,HDL)亚类对冠状动脉狭窄程度影响的相关性。方法(1)抽取2013—2014年因疑诊冠心病(coronary heart disease,CHD)入住该院老年医学科、心内科行冠状动脉造影(coronary arteriography,CAG)的患者122例,经选择性冠状动脉造影确诊为CHD患者(至少有一支冠状动脉或分支狭窄>50%)96例,其中男62例,女34例,平均年龄(60.31±8.72)岁,未诊断CHD患者26例,男10例,女16例,平均年龄(59.00±13.51)岁;(2)抽取患者空腹12 h静脉血,选择双向电泳—免疫印迹检测法24 h内测定HDL亚类,对患者冠脉造影结果(采用Gensini评分)评价冠状动脉狭窄程度;(3)计量资料用均数±标准差(x±s)表示,定性资料用χ2检验,两组比较采用独立样本的t检验,Logisitic回归分析检验与冠心病相关因素,两因素相关性采用线性相关分析。结果 (1)单因素卡方、两样本独立t检验显示性别、吸烟史、糖尿病史、收缩压、体质指数(body mass index,BMI)、腰围(waist circumference,WC)、腰臀比(waist to hip ratio,WHR)、HDL、LDL、Apo A-I、Lpa、Preβ1-HDL、HDL3b、HDL3c、HDL2b与冠心病有关,差异有统计学意义(P<0.05);(2)TG、Preβ1-HDL、HDL3b是冠心病危险因素,HDL2b是冠心病保护因素(P<0.05);(3)HDL2b与Gensini评分结果成负相关,Preβ1-HDL、HDL3b与Gensini评分结果成正相关。结论在临床诊断治疗中,HDL2b值有可能做为冠心病预测因素,Preβ1-HDL、HDL3b值可为预测和诊断CHD提供重要依据,冠心病的防治不仅要改善和促进胆固醇逆转运还要调节血脂,调整HDL亚类的构成比。Objective To investigate the relationship of high-density lipoprotein（HDL）subclasses with severity of coronary artery steno-sis in patients with Coronary angiography.Methods （1）A total of 122 consecutive patients underwent Coronary angiography were se-lected,because of suspected diagnosis of CHD was admitted to Gerontology Department,Vasculocardiology Department from 2013 to 2014 in our hospital,The confirmed diagnosis of CHD patients （At least have a coronary artery or branch stenosis＆gt;50%）96,62 males and 34 females,with an average of （60.31 ±8.72）years old,normal CAG findings patients 26,10 males and 16 females,with an aver-age of（59.00 ±13.51）years old;（2）Extraction in patients with venous blood fasting 12 hours,The contents of serum HDL subclasses were determined by two dimensional gel electrophoresis associated with immunodetection method within 24 hours.Through the evalua-tion of the results of coronary angiography in patients with coronary artery stenosis degree（by Gensini score）;（3）.measurement data with mean±standard deviation （x±s）and the qualitative data withχ2 test,Comparing the two groups using independent sample t test, Using logisitic regression test and coronary heart disease （CHD）related factors,The correlation between two factors using linear corre-lation analysis.Results （1 ）Single factor chi-square,two independent samples t test showed that sex,smoking history,history of diabe-tes mellitus,systolic blood pressure,BMI,WC,WHR,HDL,LDL,ApoA-I,Lpa,Preβ1-HDL,HDL3b ,HDL3c ,HDL2b associated with coro-nary heart disease （CHD）,The difference was statistically significant.（2）Smoking,systolic blood pressure,TG,Preβ1-HDL,HDL3b, HDL3c is coronary heart disease risk factors,HDL2b is coronary heart disease （CHD）protection factor.（3）HDL2b negative correlation with Gensini score,Preβ1- HDL,HDL3b are positively related with Gensini score.Conclusion In the clinical diagnosis and treatment, HDL2b possible as predictors for coronary heart disea

关 键 词：高密度脂蛋白亚类 冠状动脉造影 GENSINI评分 

分 类 号：R541.4[医药卫生—心血管疾病]