加味健脾益肾方对草酸钙肾结石患者术后尿骨桥蛋白的影响  

Effects of Modified Jianpi Yishen Decoction on Urinary Osteopontin of Calcium Oxalate Nephrolithiasis Patients After Operation

作　　者：王炎[1] 林峰[1] 翁雪云[1] 许旭敏 余绍龙[1] 陈智锋[1] 温志鹏[1] 

机构地区：[1]深圳市中医院,广东深圳518033

出　　处：《中国中医药信息杂志》2015年第7期36-39,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：广东省中医药局建设中医药强省科研课题(20141238)

摘　　要：目的观察加味健脾益肾方对草酸钙肾结石患者经皮肾镜碎石取石或输尿管镜碎石取石术后尿骨桥蛋白(OPN)的影响,探讨加味健脾益肾方预防草酸钙肾结石的作用机制。方法将116例草酸钙肾结石术后患者随机分为试验组62例和对照组54例。试验组服用加味健脾益肾方,隔日1次;对照组口服枸橼酸氢钾钠颗粒,每日3次。观察2组患者服药前及服药2、4周时尿OPN、尿钙、尿草酸含量。结果治疗组治疗2、4周时患者尿OPN含量与治疗前比较显著上升(P<0.05),且与对照组比较差异有统计学意义(P<0.05),对照组治疗前后OPN含量比较差异无统计学意义(P>0.05)。2组治疗后尿草酸、尿钙含量与治疗前比较,差异均无统计学意义(P>0.05)。结论加味健脾益肾方可以升高尿中OPN水平,抑制草酸钙结石形成,从而预防草酸钙肾结石经皮肾镜碎石取石或输尿管镜碎石取石术后患者结石复发。Objective To observe the effects of modified Jianpi Yishen Decoction on urinary osteopontin （OPN） in calcium oxalate nephrolithiasis patients after percutaneous nephrolithotomy （PCNL） or ureteroscope lithotomy （URL）;To clarify the mechanism of modified Jianpi Yishen Decoction on the prevention of calcium oxalate kidney stones. Methods Totally 116 calcium oxalate nephrolithiasis patients were randomly divided into trial group （62 cases） and control group （54 cases）. The trial group took modified Jianpi Yishen Decoction every other day, while the control group took potassium sodium hydrogen citrate granules three times a day. The concentrations of OPN, urinary calcium and urinary oxalic acid of the patients in the two groups were observed before treatment and 2 weeks and 4 weeks of treatment. Results The concentration of urinary OPN of 2 weeks and 4 weeks of the treatment in the trial group was significantly increased compared with before treatment （P〈0.05）, and the difference was statistically significant compared with the control group （P〈0.05）. The concentration of urinary OPN in the control group had no significant change after treatment （P〉0.05）. The differences in the concentrations of urinary calcium and urinary oxalic acid of the two groups between before and after treatment were not significant （P〈0.05）. Conclusion Modified Jianpi Yishen Decoction can effectively restrain the formation of the calcium oxalate stones by increasing the level of urinary OPN, which demonstrates effective prevention in the calcium oxalate nephrolithiasis patients after PCNL or URL.

关 键 词：加味健脾益肾方 肾结石 草酸钙 经皮肾镜碎石取石 输尿管镜碎石取石 尿骨桥蛋白 

分 类 号：R277.522.4[医药卫生—中医学]