布替萘芬治疗皮肤癣菌感染疗效Meta分析  

A Meta-analysis of the Therapeutic Efficacy of Butenafine for Skin Dermatophyte Infections

作　　者：曲晓宇[1] 张四喜[1] 张文锐[1] 宋燕青[1] 

机构地区：[1]吉林大学第一医药学部,吉林长春130021

出　　处：《中国皮肤性病学杂志》2015年第6期578-582,共5页The Chinese Journal of Dermatovenereology

摘　　要：目的系统性评价布替萘芬治疗皮肤癣菌感染的临床疗效。方法检索中国知网、万方中文数据库与MEDLINE,EMBASE和Cochran library英文数据库中布替萘芬治疗皮肤癣菌感染疗效的随机对照试验文献,"布替萘芬疗效"或"布替萘芬感染"为关键词,用Rev Man5.0软件对符合入选标准的文献中的数据进行Meta分析,评价布替萘芬治疗皮肤癣菌感染的疗效。结果共入选15篇文献,布替萘芬治疗组1 067例,对照组1 061例。停药时,布替萘芬治疗组有效率和真菌学疗效均优于对照组的有效率和真菌学疗效,差异均有统计学意义(P均<0.05)。停药后2周时,布替萘芬治疗组的有效率和真菌学疗效与对照组的有效率和真菌学疗效相似,且差异均无统计学意义(P均>0.05)。另外不良反应发生率比较,布替萘芬治疗组均明显低于对照组,差异也有统计学意义(P<0.05)。结论布替萘芬治疗皮肤癣菌感染的疗效确切,安全性高。Objective To systematically review the therapeutic efficacy of Butenafine for dermatophyte infections. Methods Key words, ＂efficacy of butenafine＂ and ＂butenafine and infection＂, were used to retrieve articles of randomized controlled trials on the efficacy of butenafine for dermatophytes infection from CNKI, WanFang data, MEDLINE, EMBASE and Cochran library. The meta-analysis of the efficacy in dermato- phyte infections was performed with RevManS. 0 software. Results A total of 15 studies were included. There were 1 067 subjects in the butenafine group and 1 061 subjects in the control group. At the end of treatment, the clinical efficacy and mycological efficacy in the butenafine group were much better than that in the control group （P 〈 0.05）. Two week follow-up, the clinical efficacy and mycological efficacy in the butenafine group were similar to that in the control group（P 〉0. 05 ）. In term of safety, the incidence of ad- verse reactions in the butenafine group was much lower than that in the control group（P 〈 0.05 ）. Conclu- sion Butenafine is certainly effective and safe for skin dermatophyte infections.

关 键 词：布替萘芬 癣菌 感染 META分析 

分 类 号：R756[医药卫生—皮肤病学与性病学]