天疱疮患者毛囊中自身抗体与病情相关性的研究进展  

Advances in the Association of Antibodies in the Follicles of Plucked Hair with Disease Severity in Pemphigus

作　　者：来学民[1] 赵玉铭[2] 

机构地区：[1]沈阳市第七人民医院皮肤科,辽宁沈阳110003 [2]中国医科大学附属第一医院皮肤科,辽宁沈阳110001

出　　处：《中国皮肤性病学杂志》2015年第6期632-634,共3页The Chinese Journal of Dermatovenereology

摘　　要：天疱疮是一种自身免疫性表皮内水疱、大疱性皮肤黏膜疾病。在正常皮肤或黏膜上出现松弛性水疱,尼氏征阳性,血清中有天疱疮抗体。病程中可见多次复发与缓解交替。糖皮质激素是目前该病的主要治疗药物,长期应用不良反应大。直接免疫荧光对了解治疗反应,指导临床的治疗,具有重要意义,但在临床上难以做反复检查。目前通过对天疱疮患者拔除的头发上残留毛囊进行直接免疫荧光的检测,发现其与病情严重程度一致。该检查可重复,创伤小,有可能成为一种指导临床糖皮质激素等减量的有效检查方法。Pemphigus is an autoimmune disease with intraepidermal blisters and bullae in the skin and mucosa. It is clinicafly characterized by loose blisters, positive Nikolsky＇s sign and presence of pemphigus antibodies IgG in serum. Disease can come and go. Currently, corticosteroids are the major drugs for pemphigus. But long term administrations of corticosteroids can cause severe side effects, Although direct immunofluorescence （DIF） of skin biopsy is useful to assess the therapeutic efficacy, it is difficulty to repeatedly take skin biopsy. However, DIF of the follicles of plucked hair well reflects the severity of pemphigus. Since examination can be easily repeated using this technique with minimal damage, it could become a valuable approach to guide the usage of corticosteroid dosage during the treatment.

关 键 词：天疱疮 抗体 毛囊 免疫荧光 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]