天然产物Longistylin A,Longistylin C和Cajanotone的全合成  

Total Synthesis of Longistylin A, Longistylin C and Cajanotone

作　　者：陈文章[1] 王聪[1] 樊玲玲[1] 王建塔[1] 岳炜洲 汤磊[1] 

机构地区：[1]贵阳医学院药学院,贵阳550004 [2]中国药科大学药学院,南京210009

出　　处：《有机化学》2015年第5期1146-1151,共6页Chinese Journal of Organic Chemistry

基　　金：教育部新世纪优秀人才支持计划(No.NNCET-12-0656);贵州省高等学校创新能力提升计划(黔教合协同创新字No.2013-04);贵州省教育厅青年基金(No.2014-300)资助项目~~

摘　　要：天然产物Longistylin A,Longistylin C和Cajanotone属于茋类化合物,具有广泛的生物活性.以3,5-二甲氧基苯甲酸为原料,以Horner-Wadsworth-Emmons(HWE)反应和1,3-sigma重排反应为关键步骤,经6步反应同时得到了Longistylin A和Longistylin C.采用3,5-二羟基苯甲酸为原料,以Barbier反应和1,3-sigma重排反应为关键步骤,经8步反应全合成得到了Cajanotone.Natural products longistylin A, longistylin C and cajanotone belong to stilbenes family and exhibit varieties of bioactivities. Using Horner-Wadsworth-Emmons （HWE） and 1,3-sigma rearrangement reactions as key steps, Iongistylin A and longistylin C have been successfully synthesized in six steps from 3,5-dimethoxy benzoic acid. Besides, using Barbier and 1,3-sigma rearrangement reactions as key steps, cajanotone has been first prepared in eight steps from 3,5-dihydroxy benzoic acid.

关 键 词：longistylin A longistylin C Cajanotone 全合成 

分 类 号：O629[理学—有机化学]