依达拉奉对高血压脑出血患者微创碎吸术后血肿引流物中超氧化物歧化酶和丙二醛的影响  

Effect of Edaravone on Superoxide Dismutase and Malondialdehyde in Hematoma Drainage after Minimally Invasive Surgery Crashing and Aspirating Hematoma in Patients with Hypertensive Intracerebral Hemorrhage

作　　者：石滴坚[1] 余野[1] 

机构地区：[1]重庆市第三人民医院,重庆400014

出　　处：《中国药业》2015年第11期47-49,共3页China Pharmaceuticals

摘　　要：目的观察微创碎吸术后依达拉奉对高血压脑出血血肿引流物中超氧化物歧化酶和丙二醛水平的影响。方法将60例高血压脑出血患者随机分为观察组和对照组,各30例,对照组采用常规治疗,观察组加用依达拉奉治疗,应用黄嘌呤氧化酶法监测血肿引流物中超氧化物歧化酶及丙二醛的动态变化。结果两组比较,观察组术后48h和72h检测血肿引流物中超氧化物歧化酶质量浓度较高,而丙二醛质量浓度较低。观察者患者总体有效率高于对照组(P<0.05)。结论依达拉奉可增高高血压脑出血血肿引流物中超氧化物歧化酶水平,降低丙二醛水平,有利于患者康复。Objective To observe the effects of edaravone on superoxide dismutase（SOD） and malondialdehyde（MDA） in hematoma drainage after minimally invasive surgery crashing and aspirating hematoma in patients with hypertensive intracerebral hemorrhage. Methods 60 patients with hypertensive intracerebral hemorrhage（HIH） were divided into the observation group （n =30） and the control group （n =30）. The control group adopted the routine treaunent, while on this basis the observation group was added with edaravone. The dynamic changes of SOD and MDA in hematoma drainage were monitored by using the xanthinoxidase method. Results The mass concentrations of SOD in hematoma drainage at postoperative 48, 72 h in the observation group were higher than those in the control group, whereas the mass concentrations of MDA were lower. The total effect rate of the observation group was higher than that of control group, the difference was statistically significant（ P 〈0. 05）. Conclusion Edaravone can increase the level of SOD and decrease the level of MDA in hematoma drainage after operation of intracerebral hemorrhage and improve the recovery of patients.

关 键 词：高血压脑出血 微创性外科手术 超氧化物歧化酶 丙二醛 依达拉奉 

分 类 号：R969.4[医药卫生—药理学] R982[医药卫生—药学]