离子色谱法测定厄贝沙坦胶囊中叠氮化物的残留量  

Determination of Azides Residual Amount in Irbesartan Capsule by Ion Chromatography

作　　者：林伟豪[1] 李东[2,3] 吴婵娟[1] 

机构地区：[1]广东省深圳市坪山新区人民医院药剂科,广东深圳518118 [2]暨南大学第二临床医学院 [3]深圳市人民医院临床药学研究室,广东深圳518020

出　　处：《中国药业》2015年第11期55-57,共3页China Pharmaceuticals

摘　　要：目的建立测定厄贝沙坦中叠氮化物残留量的离子色谱法。方法采用Ion Pac AG11-HC保护柱（50 mm×4 mm）,Ion Pac AS11-HC分析柱（250 mm×4 mm）;淋洗液采用低浓度的KOH溶液、梯度洗脱,柱温30℃,进样量25μL。结果叠氮化物离子质量浓度在0.542-2.168μg/mL范围内与峰面积线性关系良好（r=0.999 7）,方法检测限为0.25 ng,定量限为1.25 ng。结论该法简单快速,专属性强,结果准确,灵敏度高,可用于厄贝沙坦中叠氮化物残留量的检测。Objective To establish an ion chromatography method for the determination of the azides residual amount in Irbesartan Ccapsules.Methods The method was established by using the Ion Pac AG11-HC（50 mm × 4 mm） as the protection column and the Ion Pac AS11-HC（250 mm × 4 mm） as the analytical column; the elution solution adopted the low concentration of KOH-solution,the gradient elution was adopted.The column temperature was 30 ℃; the sample size was 25 μL.Results The linear range of azide ion was 0.542-2.168 μg/m L（r = 0.999 7）.The detection limit of azide by this method was 0.25 ng; the quantity limit of azide was1.25 ng.Conclusion The established method is simple,rapid,strongly specific,accurate,highly sensitive and suitable for the determination of azide residue in irbesartan.

关 键 词：厄贝沙坦胶囊 叠氮化物 离子色谱法 

分 类 号：R927.11[医药卫生—药学] R972.4