超重及肥胖对女性体外受精-胚胎移植结局的影响  

Effect of Female Overweight and Obesity on IVF-ET Outcomes

作　　者：吴海霞[1] 潘家坪[1] 滕晓明[1] 

机构地区：[1]同济大学附属上海市第一妇婴保健院生殖医学中心,上海200040

出　　处：《国际生殖健康／计划生育杂志》2015年第3期217-219,共3页Journal of International Reproductive Health/Family Planning

摘　　要：目的：评估超重及肥胖对女性体外受精-胚胎移植（IVF-ET）结局的影响。方法：回顾性分析2010年1月—2011年12月516例行IVF-ET助孕治疗、年龄〈38岁的女性患者的临床资料。入选患者按体质量指数（BMI）分为2组：BMI正常组（A组,BMI 18.5-24.9 kg/m^2）467例;超重及肥胖组（B组,BMI≥25 kg/m^2）49例。分析其IVF新鲜取卵周期的相关指标及治疗结局。结果：B组患者较A组患者促性腺激素（Gn）使用时间长和Gn用量多,人绒毛膜促性腺激素（h CG）日血清雌二醇（E2）水平低（均P〈0.05）。2组患者获卵数差异无统计学意义（P〉0.05）。A组患者卵子受精率高于B组（χ^2=8.102,P=0.004）,2组患者种植率、临床妊娠率及活产率差异均无统计学意义。结论：超重及肥胖可导致IVF-ET治疗过程中Gn使用时间延长、Gn用量增加,受精率降低,可能对IVF-ET结局有负面影响。Objective： To assess the effect of female overweight and obesity on the clinical outcomes of in vitro fertilization-embryo transferation （IVF-ET）. Methods：This is a retrospective study of 516 women aged 〈 38 years undergoing nondonor IVF cycles in a university affiliated hospital. They were classified into two groups： the normal weight group （Group A： BMI 18.5-24.9 kg/m^2, n=467） and the overweight and obese group （Group B： BMI≥25 kg/m^2, n=49）. Clinical treatment and outcomes （fertilization, implantation, pregnancy, miscarriage and live birth rate） were compared. Results：The total dose of gonadotrophin （Gn） and stimulation days in group B were significantly larger than those in group A（P〈0.05）, while the E2 level on the day of hCG administration in group B was significantly lower （P〈O.05）. There were not significant differences in the number of harvested oocytes, the implantation rate, the clinical pregnancy rate and the live birth rate between two groups （P〉0.05）. Interestingly, the fertilization rate in group A was significantly higher than that in group B （Х^2=8.102,P=0.004）. Conclusions：Female overweight and obesity results in the prolonged Gn stimulation, the increased dose of Gn and the lowered fertilization rate, which had negative effect on IVF outcomes.

关 键 词：体重 超重 肥胖症 受精 体外 胚胎移植 

分 类 号：R714.8[医药卫生—妇产科学]