MicroRNA在急性心肌梗死中的研究进展  

Progress in the research of micro RNAs in myocardial infarction

作　　者：季倩[1] 李小波[1] 张瑶俊[1] 孟培娜 邵明学[1] 陈立文[1] 朱灏[1] 田乃亮[1] 

机构地区：[1]南京医科大学附属南京第一医院心内科,210000

出　　处：《中华临床医师杂志（电子版）》2015年第9期172-175,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：急性心肌梗死(AMI)是世界上发病率及死亡率极高的疾病,其早期的正确诊断和治疗有助于减轻心肌缺血损伤、降低病死率及改善预后。目前临床上主要通过检测血清肌钙蛋白对急性心肌梗死进行诊断,但由于肌钙蛋白的释放有滞后性,因而亟须一种高敏感性、高特异性、检测简便的生物标记来提高急性心肌梗死的诊断率以及降低其死亡率。研究表明micro RNA与心肌梗死的早期诊断及预后相关,本文综述micro RNA与心肌梗死的研究进展。Acute myocardial infarction （AMI） is one of the most incident and fateful diseases in the world. Early and accurate diagnosis and treatment are the key to reduce the myocardial ischemic injury and archive satisfactory outcome. Troponin test has been used with great success for the past years and has markedly improved the diagnosis of AMI, while its release is usually hysteretic. Therefore it is urgent to develop a rapid biomarker with high sensitivity and specificity to improve the diagnosis rate and reduce mortality. This review summarized the progress in the research of microRNAs in myocardial infarction.

关 键 词：微RNA 心肌梗死 诊断 

分 类 号：R542.22[医药卫生—心血管疾病]