Indian hedgehog在软骨细胞力学信号转导作用的研究进展  

The signal transduction role of Indian hedgehog in cartilage cell mechanics

作　　者：张博[1] 郭丽[1] 田瑞媛 段王平[1] 魏垒[1] 卫小春[1] 

机构地区：[1]山西医科大学第二医院骨科骨与软组织损伤与修复山西省重点实验室,太原030001

出　　处：《中国矫形外科杂志》2015年第11期1004-1006,共3页Orthopedic Journal of China

基　　金：国家自然基金资助项目(编号:31340010);教育部2012高等学校博士学科专项科研基金(编号:201214171200040);山西省基础研究计划项目青年科技研究基金(编号:2013021036-3)

摘　　要：软骨细胞力学是近几年生物力学发展的新领域,是细胞工程和组织工程学的基础,细胞的形态、结构、功能及其新陈代谢、分化都与力学有着密切的关系。力学对维持软骨细胞生物学功能必不可少,机械应力联合其他化学分子共同调节关节软骨的生理和病理变化[1]。软骨细胞通过细胞骨架、细胞外基质、离子通道、细胞膜受体等来感受力学信号,并且结合基因表达来调控自身的代谢活动[2]。近年来研究发现Indian hedgehog为力学敏感性的基因[3]。本文主要对软骨细胞力学生物学转导机制以及与Indian hedgehog信号通路进行综述。Chondrocyte mechanics is a new field of biomechanics development in recent years, which is the foundation of cell engineering and tissue engineering. The morphology, structure, function, metabolism, differentiation have a close relation- ship with mechanics. Mechanics is essential for cartilage cell biology function, and mechanical stress, along with other chemical molecules, adjust the variation on physiology and pathophysiology of articular cartilage . Chondrocyte accept mechanical signal by the cytoskeleton, extracellular matrix, ion channels and membrane receptor , and regulate its metabolic activity through gene expression . The study found that Indian hedgehog acts as mechanical sensitivity genes in recent years . This review fo- cus on the biomechanics transduction about chondrocytes as well as the correlation with Indian hedgehog signaling pathways.

关 键 词：力学 软骨细胞 印度豪猪蛋白 

分 类 号：R318.01[医药卫生—生物医学工程]