抗菌肽与透明质酸复合敷料用于二氧化碳点阵激光术后对皮肤损伤修复效果的观察  

The effect of antimicrobial peptides and hyaluronic acid compound mask on wound healing after ablative fractional carbon dioxide laser resurfacing

作　　者：张家安[1] 周炳荣[1] 吴红巾 谢淑芬[1] 刘娟[1] 易飞[1] 骆丹[1] 

机构地区：[1]南京医科大学第一附属医院皮肤科,江苏南京210029

出　　处：《中国美容医学》2015年第10期43-46,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨抗菌肽与透明质酸复合敷料对二氧化碳点阵激光术后的修复作用。方法:24名受试者的面颊两侧分别接受二氧化碳点阵激光治疗。选择受试者左侧面颊局部外敷抗菌肽与透明质酸复合敷料,每天外用1次,连用5d;另外一侧不作处理。在激光治疗前及治疗后第1、3、7、14d检测面颊两侧经皮水分丢失量、皮肤颜色及皮肤弹性。结果:经过外敷抗菌肽与透明质酸复合敷料一侧面颊的红斑指数、黑素指数和经皮水分丢失量均显著低于对照侧;而皮肤弹性与对照侧差异无统计学意义。结论:二氧化碳点阵激光术后,使用抗菌肽与透明质酸复合敷料可促进皮肤屏障恢复并改善急性炎症反应。Objective To evaluate the benefits of antimicrobial peptides（AMPs） and hyaluronic acid（HA） compound mask on wound healing after fractional carbon dioxide laser resurfacing（Fx CR） on human skin. Methods Twenty four subjects were treated with Fx CR on the bilateral cheeks.Antimicrobial peptides and hyaluronic acid compound mask was applied on Fx CR side of left cheek.The index of erythema,melanin, transepidermal water loss（TEWL）,and overall elasticity of Fx CR side on both cheeks were measured. Results The index of erythema,melanin,and TEWL of the AMPs and HA compound mask side were significantly lower than those of without mask side. Conclusion Application of AMPs and HA compound mask is an effective method for enhancing wound healing after Fx CR,by reducing transient adverse effects such as erythema,hyperpigmentation,and increased TEWL.

关 键 词：二氧化碳点阵激光 抗菌肽 透明质酸 伤口愈合 

分 类 号：R616.4[医药卫生—外科学]