包膜病毒样颗粒疫苗研究进展  

Progress in research on enveloped VLP vaccines

作　　者：仇书兴[1] 霍玉奇[1] 黄晓媛[1] 杨晓明[2] 

机构地区：[1]武汉生物制品研究所有限责任公司,湖北武汉430207 [2]中国医药集团总公司,北京100088

出　　处：《微生物学免疫学进展》2015年第3期58-62,共5页Progress In Microbiology and Immunology

摘　　要：病毒样颗粒(VLPs)是指由病毒一个或几个结构蛋白自行组装成不含病毒基因组且不能复制、不具有感染能力的病毒样蛋白颗粒,形态结构上类似完整病毒,具有与完整病毒相似的免疫原性。VLPs可以分为两大类:无包膜VLPs和包膜VLPs,包膜VLPs被源于宿主细胞的脂质包膜包裹,包膜表面含有保护性抗原纤突。主要就包膜病毒样颗粒疫苗的结构、重组表达及免疫原性等方面的研究进展进行了综述。Virus-like particles （VLPs） consist of one or more viral coat proteins that spontaneously self-assemble into parti- cles that are antigenically indistinguishable from infectious virus or subviral particles. VLPs are non-infective and non-repli- cating, since they are essentially devoid of infectious genetic material. Based on the structure of their parental viruses, VLPs can be divided into two major categories： non-enveloped VLPs and enveloped VLPs. Enveloped VLPs are shells assembled from the capsid and/or envelope protein（s） of enveloped viruses surrounded with a lipid membrane known as the viral envelope. This envelope is derived from the host cell plasma membrane in a process termed ＂budding＂. This paper mainly illustrates the progress on enveloped VLPs, including structure, expression system and immunogenicity.

关 键 词：包膜 病毒样颗粒 表达系统 免疫原性 佐剂 

分 类 号：R392[医药卫生—免疫学]