人工关节超高分子量聚乙烯交联改性的观察  

Crosslinking modification of ultra high molecular weight polyethylene during joint arthroplasty

作　　者：佟刚[1] 田华[2] 王彩梅 王刚 

机构地区：[1]首都医科大学附属北京同仁医院骨科 [2]北京大学第三医院骨科,100191 [3]北京爱康宜诚医疗器材股份有限公司

出　　处：《中华医学杂志》2015年第21期1695-1697,共3页National Medical Journal of China

基　　金：首都市民健康项目培育（Z131100004013033）

摘　　要：目的 探讨人工关节超高分子量聚乙烯（UHMWPE）采用γ射线辐照交联及热处理的最佳条件.方法 将医用UHMWPE材料用不同剂量γ射线辐照并热处理,制备成髋关节内衬和膝关节垫片,进行摩擦磨损测试,并进行理化性能评估,依据测试结果筛选出最佳辐照交联改性方案.结果 以75 kGy剂量辐照,在150℃热处理后的UHMWPE样品磨损率最低,与未经处理的材料相比,改性后的髋臼磨损率平均降低了63.24％、膝关节垫片磨损率平均降低了59.95％.同时此改性后的UHMWPE材料具有良好的机械性能,冲击强度为83 kJ/m2、拉伸强度50.32 mPa、屈服强度21.83 mPa、断裂伸长率312％.此外,改性后的材料还具有较好的抗疲劳性能和可靠的化学性能.结论 以75 kGy剂量的γ射线辐照,在150℃下热处理,为人工关节超高分子聚乙烯交联改性的最佳条件.Objective To explore the optimal condition of crosslinking modification of ultra high molecular weight polyethylene （UHMWPE） by gamma ray irradiation.Methods The hip and knee joint samples of UHMWPE were tested with regards to friction and wear performance at different doses of 60Co radiation and heat treatment.And the optimal condition of crosslinking was determined by wear performance and physicochemical properties.Results Under the condition of 75 kGy irradiation and 150 ℃ heat treatment,crosslinked UHMWPE showed the best performance.Acetabular sample wear rate decreased 63.24% and knee sample wear rate decreased 59.95% compared with conventional UHMWPE.The modified material had excellent mechanical properties of impact strength 83 kJ/m2,tensile strength 50.32 MPa,yield strength 21.83 MPa and elongation at break 312%.Also the material showed excellent antifatigue and reliable chemical properties.Conclusion The optimal condition of crosslinking modification of UHMWPE is 75 kGy irradiation after 150 ℃ heat treatment.

关 键 词：人工关节 聚乙烯 Γ射线 磨损 

分 类 号：R318.1[医药卫生—生物医学工程]