盐酸米诺环素口腔黏附片的制备与体外考察  

Preparation and in vitro evaluation of oral adhesive tablets of minocycline hydrochloride

作　　者：张燕梅[1] 叶国健[1] 牛亚伟[1] 董晓婷[1] 秦凌浩[1] 

机构地区：[1]广东药学院药科学院,广州510006

出　　处：《中国抗生素杂志》2015年第6期433-438,共6页Chinese Journal of Antibiotics

摘　　要：目的制备长效盐酸米诺环素口腔黏附片,并进行体外性质的考察。方法对不同种类羟丙基甲基纤维素(HPMC)黏附材料进行溶胀率和黏附性的考察基础上,选用HPMC 60SH-4K为黏附剂,加入泡腾剂,PEG-6000,F68设计不同黏附片处方,比较不同处方的溶胀率、黏附力、体外释放度等指标。结果处方最佳组成为HPMC 150mg,PEG-6000 10mg,泡腾剂10mg,盐酸米诺环素12和24h累积释放度分别为58.27%和95.7%。结论盐酸米诺环素口腔黏附片制备方便,具有缓释的效果,对牙周炎有望达到较好的治疗效果。Objective To prepare and in vitro evaluate an long-term oral adhesive minocycline hydrochloride tablets. Methods The swelling rate and adhesive strength of various types of HPMC were investigated. HPMC 60SH-4K, as adhesive material, was used to prepare various formulations of oral adhesive tablets. Each formulation was added with different quantities of effervescent agents, PEG-6000 or F68 and the swelling rate, adhesive strength and dissolution profiles of these 8 formulations were compared. Results The optimal formula was 150mg ofHPMC, 10mg of PEG-6000, and 10mg of effervescent agent. The cumulative released percentage of minocycline within 12 and 24h were 58.27% and 95.7% respectively. Conclusion The preparation procedure of oral adhesive tablet is simple and drug loaded tablets can produce sustained-release effect, which provides the potential use for treatment of periodontitis.

关 键 词：盐酸米诺环素 羟丙甲基纤维素 黏附片 体外评价 

分 类 号：R978.14[医药卫生—药品]