南京34家医院近几年碳青霉烯类抗菌药物使用趋势  

Recently years trend of carbapenem consumption in 34 hospitals of Nanjing

作　　者：许亚洲[1] 曹加[1] 

机构地区：[1]南京医科大学第一附属医院,南京210029

出　　处：《中国抗生素杂志》2015年第6期451-458,共8页Chinese Journal of Antibiotics

基　　金：江苏省卫生厅面上科研课题(No.H201305);江苏省人民医院诊疗新技术新项目立项(No.院发[2012]187号);科技部科技重大专项"重大新药创制"(No.2011ZX09302-003-02);江苏高校优势学科建设工程资助项目(No.JX10231801)

摘　　要：目的评价与分析近4年碳青霉烯类(CB)抗菌药物在南京34家医院药物使用趋势。方法根据WHO推荐的限定日剂量(DDD),统计通用名和商品名用药频度(DDDs)、用药金额、增长率(%)、构成比(%)及趋势、用药金额与DDDs序号比值、日均费用(DDC)(元/日),采用SPSS软件对其进行统计学分析。结果 2010—2013年南京34家医院CB药物的通用名和商品名分别从6种和15种减为5种和11种;每年总CB用药金额和总DDDs均呈不断增加趋势(P<0.01),但2个总指标的增长率呈逐年下降趋势(P<0.05),每种CB的DDC呈明显下降趋势(P<0.05),比阿培南DDC明显高于其他CB药物(P<0.05)。前5位商品名[泰能(亚胺培南/西司他丁)、美平(美罗培南)、倍能(美罗培南)、天册(比阿培南)和安信(比阿培南)]的DDDs和用药金额总构成比均>80%。结论南京34家医院CB用药金额和使用量均呈增长趋势,但增长率减缓,药物品种数量减少,DDC呈下降趋势,用药金额和用药量集中在前5位商品名,进口药品仍稳居第一和第二位。Objective To evaluate trend of carbapenems （CB） consumption in 34 hospitals of Nanjing in the past four years. Methods CB consumption （DDDs） was expressed as defined daily dose （DDD） recommended by the World Health Organization. DDDs, drug expenses, growth rate （%）, constituent ratio （%） and trend, the serial number ratio of drug expenses and DDDs, average daily cost （DDC） （yuardday） were investigated in CB generic drug name and trade name. The data were analyzed using SPSS Version 13.0. Results CB varieties quantity was decreased from 6 and I5 to 5 and II respectively for generic drug name and trade name in 34 hospitals of Nanjing from 2010 to 2013. Annual total drug expenses and total DDDs in CB consumption showed increased trend（P〈0.01）, but their growth rates showed decreased trend （P〈0.05） year by year. The DDC of each CB consumption showed decreased trend （P〈0.05）. The DDC of biapenem consumption was higher than that of other CB consumption significantly（P〈0.05）. Total drug expenses and total DDDs of the top five [Tai-neng（imipenem/cilastatin）, Mei-ping（meropenem）, Beineng（meropenem）, Tian-ce（biapenem） and An-xin（biapenem）] in the consumption of CB trade names were all more than 80% constituent ratio respectively. Conclusion Annual total drug expenses and total DDDs of CB consumption showed growth trend in 34 hospitals of Nanjing, but their growth rates, drug varieties quantity and DDC all slowed decreased trend. Total drug expenses and total DDDs of CB consumption all concentrated on the top five rankings in CB trade names. Imported drugs in CB consumption was still steadily the first and second rankings.

关 键 词：碳青霉烯类用药频度 用药金额 增长率 日均费用 趋势分析 

分 类 号：R378[医药卫生—病原生物学]