Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15K to 333.15K  

作　　者：Md Khalid Anwer Faiyaz Shakeel 

机构地区：[1]Department of Pharmaceutics, College of Pharmacy, Salman Bin Abdulaziz University [2]Center of Excellence in Biotechnology Research, King Saud University [3]Department of Pharmaceutics, College of Pharmacy, King Saud University

出　　处：《Chinese Journal of Chemical Engineering》2015年第5期812-815,共4页中国化学工程学报（英文版）

基　　金：supported by the Deanship of Scientific Research, Salman Bin Abdulaziz University, Al-Kharj, Saudi Arabia (47H/1433)

摘　　要：The aim of present study was to measure and correlate the solubility of poorly water-soluble flavonoid diosmin in water, ethanol, isopropyl alcohol （IPA）, polyethylene glycol-400 （PEG-400） and β-cyclodextrin （β-CD） aqueous solution （0.02 mol·L^-1 ）. The solubility of diosmio was measured using the shake flask method from （298.15 to 333.15） K at atmospheric pressure. The experimental solubilities of diosmin were regressed by the modified Apelblat model with a relative deviation in the range of 0.048% to 5.940%. The correlation coefficients were observed in the range of 0.9957 to 0.9995. The solubility of diosmin was found to be increased with temperature in all sample matrices investigated. The mole fraction solubility of diosmin was found to be higher in 5-CD aqueous solution and PEG-400 as compared to water, ethanol and IPA. Based on solubility data of present study, diosmin was considered as practically insoluble in water, insoluble in ethanol ＆ IPA and soluble in PEG- 400 and β-CD aqueous solution.The aim of present study was to measure and correlate the solubility of poorly water-soluble flavonoid diosmin in water, ethanol, isopropyl alcohol(IPA), polyethylene glycol-400(PEG-400) and β-cyclodextrin(β-CD) aqueous solution(0.02 mol·L-1). The solubility of diosmin was measured using the shake flask method from(298.15 to333.15) K at atmospheric pressure. The experimental solubilities of diosmin were regressed by the modified Apelblat model with a relative deviation in the range of 0.048% to 5.940%. The correlation coefficients were observed in the range of 0.9957 to 0.9995. The solubility of diosmin was found to be increased with temperature in all sample matrices investigated. The mole fraction solubility of diosmin was found to be higher in β-CD aqueous solution and PEG-400 as compared to water, ethanol and IPA. Based on solubility data of present study, diosmin was considered as practically insoluble in water, insoluble in ethanol & IPA and soluble in PEG-400 and β-CD aqueous solution.

关 键 词：Apelblat model Cyclodextrin Diosmin Solubility Thermodynamics 

分 类 号：TQ460.72[医药卫生—药物分析学]