应用fMRI技术探查静息态经前期综合征肝气郁证患者中枢脑区定位  

Application of fMRI Technology in Exploration of Central Brain Localization among Premenstrual Syndrome Patients with Liver-qi Depression in Resting-state

作　　者：高冬梅[1] 于艳红[1] 侯艳娇[1] 刘晓琴[1] 乔明琦[1] 

机构地区：[1]山东中医药大学中医基础理论研究所,济南250355

出　　处：《世界科学技术-中医药现代化》2015年第4期800-804,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(81473558):经前情感障碍肝气逆;郁两证相关脑功能定位与脑功能连接特征;负责人:高冬梅;国家自然科学基金委重点项目(30930110):肝疏泄失常与调肝方药对不同脑区功能的影响及其机制研究;负责人:乔明琦

摘　　要：目的:探寻与经前期综合征肝气郁证发病密切相关的脑区。方法:采用BOLD-功能磁共振成像技术,影像学数据基于matlab平台的SPM 8软件以及rest软件进行图片处理,每个簇块体积阈值(Cluster)大于389个连续体素,单体素阈值P<0.05(校正后)的脑区定义为差异有统计学意义的区域,病例组和对照组采用双样本t检验。结果:PMS肝气郁证患者与正常对照相比,额叶、枕叶、岛叶、边缘叶、基底核、扣带回等脑区激活增强。结论:PMS肝气郁证患者发病与额叶、枕叶、岛叶、边缘叶、基底核、扣带回等脑区有关。This study was aimed to explore brain regions which were closely related to the disease onset of premenstrual syndrome （PMS） with liver-qi depression. The BOLD-functional magnetic resonance imaging （fMRI） was used in the study. The processing of imaging data was based on the SPM 8 software and the REST software of the matlab platform. Each cluster was more than 389 continuous voxel. The brain region with single voxel of P 〈 0.05 （corrected） was defined as region with statistical significance. The 2 Sample T-Test was applied in the case group and the control group. The results showed that compared with the normal control group, the frontal lobe, occipital lobe, insula, limbic lobe, basal nuclei, and cingulate gyrus were activated in the PMS with liver-qi depression cases. It was concluded that the disease onset of PMS with frontal lobe, occipital lobe, insula, limbic lobe, basal liver-q/depression cases was related to brain regions such as nuclei, and cingulate gyrus.

关 键 词：经前期综合征 肝气郁证 FMRI技术 脑区定位 

分 类 号：R271.115[医药卫生—中医妇科学]