血管内皮生长因子基因936C/T多态性与子痫前期相关性的Meta分析  

Association between 936C/T Polymorphism in VEGF Gene and Preeclampsia Risk: A Meta-Analysis

作　　者：贺艺 何子奇[2] 刘菊芳 原瑞霞 左红霞[3] 翁鸿 

机构地区：[1]咸宁市中心医院(同济咸宁医院)产科,湖北咸宁437100 [2]广西医科大学第一附属医院泌尿外科,南宁530021 [3]湖北医药学院附属太和医院循证医学中心,湖北十堰442000 [4]武汉大学中南医院循证与转化医学中心,武汉430071

出　　处：《中国循证医学杂志》2015年第6期639-645,共7页Chinese Journal of Evidence-based Medicine

基　　金：湖北医药学院附属太和医院2013年循证医学"苗圃基金"项目(编号:EBM2013004)

摘　　要：目的系统评价血管内皮因子(vascular endothelial growth factor,VEGF)基因936C/T多态性与子痫前期(preeclampsia,PE)发病风险的相关性。方法计算机检索Pub Med、EMbase、The Cochrane Library(2014年第11期)、CBM、CNKI、VIP和Wan Fang Data,查找关于VEGF基因936C/T多态性与PE发病风险相关性的病例-对照研究,检索时限均为建库至2014年11月。由2位评价员按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果最终纳入9个病例-对照研究,共计904例PE患者和1 113例对照。Meta分析结果显示,VEGF基因936C/T多态性与总人群PE发病风险有相关性[T vs.C:OR=1.61,95%CI(1.17,2.22),P=0.003;TT vs.CC:OR=2.65,95%CI(1.37,5.11),P=0.004;CT vs.CC:OR=1.55,95%CI(1.09,2.22),P=0.02;TT+CT vs.CC:OR=1.68,95%CI(1.15,2.45),P=0.007;TT vs.CT+CC:OR=2.19,95%CI(1.31,3.68),P=0.003]。亚组分析结果显示,VEGF基因936C/T多态性可能与亚洲人群发病风险有相关性,而与高加索人群发病风险无相关性。结论 VEGF基因936C/T多态性可能与亚洲人PE的发病风险相关。由于纳入研究数量及质量的限制,该结论需进一步进行验证。Objective To systematically evaluate the association between 936C/T polymorphism in vascular endothelial growth factor（VEGF） gene and the risk of preeclampsia（PE）. Methods Such databases as PubMed, EMbase, The Cochrane Library（Issue 11, 2014）, CBM, CNKI, VIP, and Wan Fang Data were searched up to November 2014, to collect case-control studies of the association between 936C/T polymorphism in VEGF gene and the risk of PE. Two reveiwers independently screened studies according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias of included studies. And then, meta-analysis was conducted using Rev Man 5.3 software. Results A total of nine case-control studies involving 904 PE patients and 1 113 controls were included. The results of meta-analysis showed that, significant association was found between VEGF gene 936C/T polymorphism and the risk of PE in the total analysis（T vs. C： OR=1.61, 95%CI 1.17 to 2.22, P=0.003; TT vs. CC： OR=2.65, 95%CI 1.37 to 5.11, P=0.004; CT vs. CC： OR=1.55, 95%CI 1.09 to 2.22, P=0.02; TT＋CT vs. CC： OR=1.68, 95%CI 1.15 to 2.45, P=0.007; TT vs. CT＋CC： OR=2.19, 95%CI 1.31 to 3.68, P=0.003）. In the subgroup analysis, significant association of the polymorphism was found in Asians but not in Caucasians. Conclusion VEGF gene 936C/T polymorphism may be associated with PE risk in Asians. Due to limited quantity and quality of the included studies, the conclusion should be assessed in further studies.

关 键 词：子痫前期 基因 多态性 血管内皮生长因子 META分析 

分 类 号：R714.244[医药卫生—妇产科学]