小剂量雄激素联合中药治疗特发性少弱精子症的临床效果  

Clinical effect of low dose androgen combined with traditional Chinese medicine in the treatment of idiopathic oligoasthenospermia

作　　者：潘杰[1] 谢文锋[1] 吴俊雁 刘文[1] 刘燕青[1] 

机构地区：[1]英德市人民医院泌尿外科,广东英德513000

出　　处：《中国计划生育和妇产科》2015年第6期9-11,共3页Chinese Journal of Family Planning & Gynecotokology

摘　　要：目的 观察小剂量雄激素联合中药治疗特发性少弱精子症的临床效果。方法 选取2012~2013年在英德市人民医院就诊的214例特发性少弱精子症患者的临床资料,根据不同用药方法分为雄激素组和对照组,其中雄激素组136例,采用小剂量雄激素（安雄40 mg,2次/d）联合中药（复方玄驹胶囊1.26 g,3次/d）治疗;对照组78例单纯使用中药治疗。随访半年,观察两组对象的精液参数恢复情况、配偶妊娠情况。结果 两组患者治疗后的精子总数[（55.48±8.23）、（54.03±12.42）百万/次]、前向运动精子总数[（32.78±4.68）、（32.08±4.89）百万/次]较治疗前的精子总数[（23.28±4.03）、（23.04±4.78）百万/次]、前向运动精子总数[（9.39±1.99）、（9.19±1.98）百万/次]均有改善（P〈0.05）,但两组间治疗后的精子总数、前向运动精子总数比较,差异均无统计学意义（P〉0.05）。雄激素组配偶妊娠率为11.03%（15/136）,对照组为11.54%（9/78）,两组间比较差异无统计学意义（P〉0.05）。结论 小剂量雄激素联合中药与单独使用中药治疗特发性少弱精子症的临床效果无明显差异。Objective To observe the clinical effect of low dose androgen combined with traditional Chinese medicine in the treatment of idiopathic oligoasthenospermia.Methods Clinical data of 214 patients with idiopathic oligoasthenospermia in The People’ s Hospital of Yingde City from 2012 to 2013 were selected.All cases were divided into testosterone group and control group, patients in testosterone group （ n=136 ） were given small dose of androgen （ male 40 mg, bid ） combined with traditional Chinese medicine（compound Xuanju capsule 1.26 g, tid）, patients in control group （n=78） were given traditional Chinese medicine only. After 6 months followed-up, the semen parameters and recovery pregnancy situation of the two groups were observed.Results The total number of sperm and number of forward movement sperm after treatment [ （ 55.48 ±8.23 ） million, （ 54.03 ±12.42 ） million;（32.78 ±4.68）million,（32.08 ±4.89）million respectively] improved than those before treatment[（12.28 ±4.03）million,（23.04±4.98）million;（9.39 ±1.99） million,（9.19 ±1.98） million respectively] in both groups （ P 〈0.05）.The difference in total number of sperm and number of forward movement sperm after treatment between two groups had no significance （ P〉0.05 ） .The pregnancy rate of the androgen group was 11.03 % （ 15/136 ） , while the control group was 11.54 % （ 9/78 ） , there was no statistically significant difference between two groups （ P〉0.05） .Conclusion The small dose of androgen combined with traditional Chinese medicine and traditional Chinese medicine alone show no significant difference in treatment of idiopathic asthenospermia.

关 键 词：少精子症 弱精子症 雄激素类 中药 治疗结果 

分 类 号：R698.2[医药卫生—泌尿科学]